Development of natural gum based glipizide mucoadhesive microsphere.

The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, sphrerical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere.

Medicated chewing gum: An unconventional drug delivery system.

Medicated chewing gum has a history for about a century. Now-a-days it is considered to be a potential and conve-nient modified release drug delivery system which can be used in pain relief medication, smoking cessation, travel illness, freshening of breath, prevention of dental caries, alleviation of xerostomia, vitamin or mineral supplementa-tion etc. Medicated chewing gums are prepared by using a water insoluble gum base with water soluble bulk portion. This formulation offers both local and systemic effects and has a range of advantages over conventional oral solid dosage forms. USP currently has no in vitro release testing apparatus for the evaluation and determination of drug release from the prepared chewing gums. But European Pharmacopoeia adopted a compendial apparatus to do so. Medicated chewing has drawn attention to the researchers as potential drug delivery system and it could be a com-mercial success in near future.

Analgesic and CNS depressant activity of the crude extract of Sesbania grandiflora.

Sesbania grandiflora, a plant of Fabaceae is full of various pharmacologically important components like, alkaloids, flavanoids, tannins, triterpenes, gums, mucilage, and anthraquinone glycosides. From different previous research documents, various functions of different parts like leaf, flower, seed and also other parts of the plant have been known. For this experiment the leaf extract is used. Basically, the objective of the research work was to bring out the pharmacological effects (CNS and analgesic activity) of the leaf extract of the plant. The investigations had brought out the significant effects of extract. Hence, CNS depressant and analgesic drug can be produced from the leaf of Sesbania grandiflora through a suitable formulation.

Medicated chewing gum: An unconventional drug delivery system.

Medicated chewing gum has a history for about a century. Now-a-days it is considered to be a potential and conve-nient modified release drug delivery system which can be used in pain relief medication, smoking cessation, travel illness, freshening of breath, prevention of dental caries, alleviation of xerostomia, vitamin or mineral supplementa-tion etc. Medicated chewing gums are prepared by using a water insoluble gum base with water soluble bulk portion. This formulation offers both local and systemic effects and has a range of advantages over conventional oral solid dosage forms. USP currently has no in vitro release testing apparatus for the evaluation and determination of drug release from the prepared chewing gums. But European Pharmacopoeia adopted a compendial apparatus to do so. Medicated chewing has drawn attention to the researchers as potential drug delivery system and it could be a com-mercial success in near future.

Analgesic and CNS depressant activity of the crude extract of Sesbania grandiflora.

Sesbania grandiflora, a plant of Fabaceae is full of various pharmacologically important components like, alkaloids, flavanoids, tannins, triterpenes, gums, mucilage, and anthraquinone glycosides. From different previous research documents, various functions of different parts like leaf, flower, seed and also other parts of the plant have been known. For this experiment the leaf extract is used. Basically, the objective of the research work was to bring out the pharmacological effects (CNS and analgesic activity) of the leaf extract of the plant. The investigations had brought out the significant effects of extract. Hence, CNS depressant and analgesic drug can be produced from the leaf of Sesbania grandiflora through a suitable formulation.

Enhancement of oral bioavailability and solid dispersion: A review.

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Most of the newly invented chemical entities are poorly water soluble. As a result formulating them as oral solid dosage forms is a hurdle to the specialists. Many techniques have been exercised to improve oral bioavailability of drugs. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. Different formulation strategies have been taken to prepare solid dispersions. It is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability. This review paper will focus on different aspects of solid dispersion preparation; their advantages, major challenges and preparation methods.

Formulation and comparison of in vitro release profile of hydrophilic and hydrophobic polymer based Naproxen matrix tablets.

The study was aimed to investigate the effect of polymer on the release profile of Naproxen from different percentages of HPMC 5cps and Kollidon SR based matrix systems. Different amount of HPMC and Kollidon SR were used to develop matrix builder in the four proposed formulations (F1-F4) for the study of release rate retardant effect at 25% and 35% of total weight of tablet matrix respectively. The tablets were prepared by direct compression method. The granules and tablets were evaluated for their physical properties and they did not show any significant variations and were found to have good physical integrity. The dissolution study of those proposed formulations were carried out in the simulated intestinal medium (pH 7.4) for 8 hours using USP paddle method with 50 rpm at 37±0.5⁰C. HPMC is hydrophilic and Kollidon SR is hydrophobic in nature. Statistically significant difference were found among the drug release profile from different percent of polymer and the release mechanisms were explored and explained with zero order, Higuchi and Korsmeyer equations. The release of Naproxen from F-1 and F-2 very closely followed Korsmeyer release kinetics where F-3 and F-4 best fitted with Higuchi model. The cumulative percent release of Naproxen was highest in F-2 containing 35% of HPMC. On the basis of results, it was found that the profile of F-1 formulation was the best among the four formulations. Between these two polymers, HPMC showed better percentage of release and Kollidon SR showed better release retardant effect.