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1.
Benha Medical Journal. 2008; 25 (1): 447-460
Dans Anglais | IMEMR | ID: emr-105910

Résumé

This study included forty newly diagnosed children with acute lymphoblastic leukemia [ALL]. On admission blood samples were taken from each patient for cytogenetic analysis by G-banding and it was successful in 37/40 patients [Gr. A] Normal karyotype was present in 20 cases [54.1%] out of 37.On the other hand numerical and structural aberrations were seen in 13 cases [35.1%] and 3 cases [8.1%] respectively; while both aberrations were detected in only one case [2.7%]. The study of the Giemsa banded chromosomes of the hyperdiploid cases showed that chromosome 21 was mostly added, followed by chromosomes [6,10 and X],chromosomes [4 and 14], number [15,17,and 18], [5 and 8], chromosome 16, and finally chromosomes [9 and 20] in that descending frequency. Hyperdiploid ALL have good prognosis on remission therapy as indicated by their chromosomal analysis. Hypodiploid karyotype was present in four cases of [Gr. A] one male and 3 females who showed poor prognosis and short duration of survival. Tetraploidy was encountered in only two male cases .One case died during his treatment period and other one showed bad prognosis as indicated by his blood analysis after treatment. Translocation t [4;l 1] [q21;q23] was found in one female and one male patients [5.4%]. The female died 3 weeks after diagnosis, while the male patient showed poor prognosis after one month of conventional chemotherapy. Another translocation t [l;19] [q23;p13] was found in 2 male patients [5.4%], they were alive after one month of treatment and they showed good prognosis during the remission induction stage. These findings imply that the accurate identification of chromosomal abnormalities in ALL patients is essential for diagnosis and may be of great value in predicting the prognosis of such cases. After 4 weeks of chemotherapeutic treatment, second blood samples from 32 cases [Gr. B] were cytogenetically normal. The remaining eight cases showed: four of them died 2 weeks after diagnosis [one teraploidy male; two hypoploid females; and one translocation [4; 11] female]; one case discontinued [hypodiploid male]; and three cases failed to remission induction [one hyper-diploid female, one tetraploid male, and one translocation [4;11] male]


Sujets)
Humains , Mâle , Femelle , Enfant , Analyse cytogénétique , Aberrations des chromosomes , Antigènes CD20/sang , Antigènes CD19 , Antigènes CD24 , Cellules de la moelle osseuse/cytologie
2.
Egyptian Journal of Medical Laboratory Sciences. 2007; 16 (2): 89-97
Dans Anglais | IMEMR | ID: emr-82213

Résumé

Leukemia is the most common malignancy of childhood [33%] where Acute Lymphoblastic Leukemia [ALL] is the most common type in children. is to study the effect of ALL on complete blood count [CBC] and on some important biochemical parameters as total protein, albomin, globulin, uric acid, lactate dehydrogenase [LDH], erythrocyte superoxide dismutase [eryth. SOD] and erythrocyte glucose-6 -phosphate dehydrogenase[eryth. G-6-PD]. Also to measure total DNA and RNA content in all the samples. Moreover to carry out a comparative study of these parameters before and after treatment in contrast to control group. This study included forty newly diagnosed children with [ALL] in National Cancer Institute [NCI], Cairo University. Blood samples on admission [Gr. IIA] and after 4 weeks of chemotherapeutic treatment [Gr. IIB] were analyzed. Four cases died 2 weeks from diagnosis, one case discontinued, and one case failed to remission induction. CBC revealed a significant remarkable decrease in the hemoglobin content, RBCs and platelet count in [Gr. IIA] and these parameters were improved in [Gr. IIB]. A significantly marked elevation in WBCs and blast cells were recorded in [Gr. IIA]. On remission they returned to their normal level in [Gr. IIB]. Total DNA and RNA contents revealed a significant remarkable elevation in [Gr. IIA], while after 4 weeks of treatment they returned to normal level [Gr. IIB]. G-6-PDH showed significant increase in [Gr. IIA] while SOD activity showed high significant decline in [Gr. IIA]. After treatment both G- 6-PD and SOD showed significant improvement [Gr. IIB]. One month of chemotherapeutic treatment is not enough to achieve complete hematological remission for Egyptian [ALL] children in contrast to European reports. Biochemical parameters returned to their normal level, yet G-6-PD and SOD activities were improved largely. Also measurement of G-6-PD and SOD activities and DNA and RNA contents are useful markers to follow up ALL children after chemotherapeutic treatment


Sujets)
Humains , Mâle , Femelle , Enfant , Marqueurs biologiques , Glucose 6-phosphate dehydrogenase , Superoxide dismutase , Numération des plaquettes , Études de suivi
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