Résumé
This study has been conducted to look at the and acid effect of Neem and to compare the effect of leaf extract with the pure compound nimolicine on the gastric acidity. Nimolicine has been studied for its anti acid effect for the first time. Experimental study. This study was conducted in the department of Physiology, Baqai Medical College and the Department of Pharmacology in Baqai Institute of Pharmaceutical Sciences, Karachi. Ethanol induced gastric ulcers in albino rats were treated with methanolic neem leaf extract [800mg/day for 5 days] and nimolicine [1%/day for 3 days] and the gastric acid secretion was estimated. The control of the treated group was given peanut oil 1 ml/day for 5 days. The effect on gastric secretion was compared with the effect of anti-ulcer drugs cimetidine [50 mg/kg for 7-10 days] and omeperazole [2.5 mg/kg/day for 7-14 days]. Neem leaf extract is a better suppressor of H-ion secretion compared to nimolicine but both neem leaf extract and nimolicine did not show a significant suppression of acid compared to ranitidine and omeperazole. The comparison between control and ranitidine in suppression of acid was significant. Methanolic NLE and neem compound nimolicine do not decrease gastric acidity and their role as anti-ulcer agents may be because of other mechanisms which need to be studied