Résumé
[99m]Tc-labeled amine thiophene ligand might be a potential candidate for brain imaging. The purpose was to investigate the uptake of a radiolabeled drug in the brain. In this study, a tetradentate amine-thiophene-dione ligand was synthesized by the reaction of thiophene-2-carboxaldehyde with ethane-1,2-diamine and reducing with NaBH4. The ligand system was characterized by elemental analysis, FTIR and [1]H NMR. Radiolabeling of the complex with [99m]Tc was performed by reducing with stannous ions. The radiochemical purity of the radiolabeled drug was determined by paper chromatography [PC] and instant thin layer chromatography [ITLC]. Bioevaluation of the [99m]Tc complex was studied in rabbits. The yield of the final product was 4.42 g [60%] and the characterization data confirmed the synthesis of the final product. The efficacy of radiolabeling was >98%. A significant uptake was observed in the brain which retained significantly up to 4h. The data indicate that the proposed system may be suitable for brain imaging in future clinical applications