RÉSUMÉ
It is the most common hereditary kidney disease. Its diagnosis is easy by ultrasound. To evaluate the clinical, epidemiological and evolutionary profile of dominant polycystic kidney and the various complications of the disease. A retrospective study of 200 cases of dominant polycystic kidney [1998 - 2008] with analysis of clinical, biological and ultrasound parameters. The average was 44 +/- 17 years with a sex ratio of 0.50. Hepatic localization was found in 19% of cases. 57.2% of patients had hypertension, 20.5% had repeated urinary infections and 5.4% have kidney stones. 35% of patients [70 cases] were lost and 65% of patients [130 cases] received a follow-up, including: 26.2% [35 cases] had a terminal stage renal failure, 13.8% [18 cases] have worsened the renal function during follow-up [elevation of creatinine more than 25% of baseline], 14.6% [19 cases] have maintained a stable renal and 45.4% [58 cases] have maintained normal renal function. Its insidious and progressive development to end-stage renal failure is the severity of the disease. Many prognostic factors of progression of renal failure are described in the literature and some of which are raised in our series: genetic [PKD1, PKD2], clinical [advanced age, hypertension, kidney stones] and biological [anemia and albuminuria]. In front of the severity of prognosis, the only was to the early follow up is the family screening to reduce morbidity and delay the installation of end-stage renal failure