Résumé
Angiogenesis inhibition is one of the fast developing approaches against tumor proliferation and metastasis. The angiogenesis-inhibition property of naturally-occuring peroxisome proliferator-activator receptor (PPAR) ligands, particularly of linoleic and linolenic acids that are present in commercially available soy bean oil, was investigated using chrorioallantoic membrane (CAM) assay. Human recombinant fibroblast growth factor (rhFGF) was utilized to stimulate human growth conditions on the CAM. Three groups consisting of 20 eggs each were treated with gelatin sponges containing: (1) rhFGF alone, the negative control; (2) soy bean oil and rhFGF, the treatment group; and. (3) rosiglitazone and rhFGF, the positive control. After incubation for 5 days, both macroscopic and microscopic methods of counting were employed. The treatment group demonstrated inhibition although it did not differ significantly from the negative control group (a=0.05, df=35, tcr=2.03, t=1.92). (Author)