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1.
Annals of Pediatric Endocrinology & Metabolism ; : 207-211, 2019.
Article Dans Anglais | WPRIM | ID: wpr-762609

Résumé

Müllerian duct aplasia-renal aplasia-cervicothoracic somite dysplasia (MURCS) association is a unique development disorder with four common types of malformations that include uterine aplasia or hypoplasia, renal ectopy or agenesis, vertebral anomalies, and short stature. The majority of MURCS patients are diagnosed with primary amenorrhea from late-adolescence. However, a few cases with MURCS association are not well diagnosed during childhood and long-term outcomes are not well reported. We report a case of an 8-year-old girl with MURCS association who presented with recurrent urinary tract infections and multiple congenital malformations, and who was followed for 10 years until adulthood. MURCS association should be considered as one of the differential diagnoses when evaluating prepubertal females with vertebral and renal malformations.


Sujets)
Enfant , Femelle , Humains , Aménorrhée , Diagnostic différentiel , Études de suivi , Somites , Infections urinaires
2.
International Neurourology Journal ; : 179-179, 2019.
Article Dans Anglais | WPRIM | ID: wpr-764127

Résumé

No abstract available.

3.
International Neurourology Journal ; : 1-2, 2019.
Article Dans Anglais | WPRIM | ID: wpr-764106

Résumé

No abstract available.

4.
International Neurourology Journal ; : S1-S1, 2017.
Article Dans Anglais | WPRIM | ID: wpr-191810

Résumé

No abstract available.


Sujets)
Comportement coopératif , Médecine , Technologie
5.
International Neurourology Journal ; : 1-2, 2017.
Article Dans Anglais | WPRIM | ID: wpr-109029

Résumé

No abstract available.


Sujets)
Vessie urinaire
6.
International Neurourology Journal ; : 247-258, 2017.
Article Dans Anglais | WPRIM | ID: wpr-222414

Résumé

PURPOSE: The pathophysiological role of detrusor overactivity (DO) in the bladder, which is commonly observed in various bladder diseases, is not well understood. DO appears in bladder outlet obstruction (BOO), and may continue even after subsequent deobstruction. DO therefore provides an excellent opportunity to observe molecular biological changes. METHODS: In this study, to understand the molecular effects of persistent DO after BOO induction and deobstruction, we performed awake cystometry on female Sprague-Dawley rats divided into 4 groups: a sham group, a BOO group, a deobstructed group with DO after BOO (DDO), and a deobstructed group without DO after BOO (non-DDO). Total RNA was extracted from the bladder samples, and gene expression profiles were compared between the sham and model groups. RESULTS: DO was observed in 5 of the 6 rats (83%) in the BOO group, and in 6 of the 13 rats (46%) in the deobstructed group. The non-DDO group showed a significantly greater residual volume than the DDO group. Through a clustering analysis of gene expression profiles, we identified 7,532 common upregulated and downregulated genes, the expression of which changed by more than 2 fold. In the BOO group, 898 upregulated and 2,911 downregulated genes were identified. The non-DDO group showed 3,472 upregulated and 4,025 downregulated genes, whereas in the DDO group, only 145 and 72 genes were upregulated and downregulated, respectively. CONCLUSIONS: Abnormal function and gene expression profiles in bladders after BOO were normalized in the BOO rats with DO after deobstruction, whereas in those without DO, abnormal function persisted and the gene expression profile became more abnormal. DO may play a protective role against the stress to the bladder induced by BOO and deobstruction as a form of adaptive neuroplasticity.


Sujets)
Animaux , Femelle , Humains , Rats , ADN , Analyse de profil d'expression de gènes , Expression des gènes , Analyse sur microréseau , Plasticité neuronale , Rat Sprague-Dawley , Volume résiduel , ARN , Transcriptome , Obstruction urétrale , Maladies de la vessie , Obstruction du col de la vessie , Vessie urinaire , Vessie hyperactive
7.
International Neurourology Journal ; : 1-2, 2016.
Article Dans Anglais | WPRIM | ID: wpr-223253

Résumé

No abstract available.


Sujets)
Défaillance cardiaque , Coeur , Apprentissage , Vessie urinaire
8.
International Neurourology Journal ; : 273-273, 2016.
Article Dans Anglais | WPRIM | ID: wpr-148121

Résumé

No abstract available.

9.
International Neurourology Journal ; : 171-171, 2016.
Article Dans Anglais | WPRIM | ID: wpr-10456

Résumé

No abstract available.


Sujets)
Facteur de transcription NF-kappa B , Protein kinases
10.
International Neurourology Journal ; : 53-54, 2015.
Article Dans Anglais | WPRIM | ID: wpr-71450

Résumé

No abstract available.

11.
International Neurourology Journal ; : 68-76, 2014.
Article Dans Anglais | WPRIM | ID: wpr-53933

Résumé

PURPOSE: The aim of this study was to apply a new surgical procedure that allows for the successful monitoring of intraurethral pressure (IUP) changes in the cystometry of awake Sprague-Dawley rats. METHODS: Twenty-six female Sprague-Dawley rats were grouped according to the catheterization method (bladder only; bladder and urethra; or bladder, urethra, and abdomen). Using an arbitrarily determined initial point of the first phase among four rat micturition phases on the simultaneous curves as a reference point, we compared the time differences to the points on an intravesical pressure (IVP) and those on IUP or a detrusor pressure (DP) curve from intra-abdominal pressure (IAP). RESULTS: In awake rat, the start of urethral flow on IUP curve corresponded to the initial point of the second phase, which is same to the results on the anesthetized rat. However, certain results, such as micturition pressure (MP) and intraluminal pressure high-frequency oscillations (IPHFOs), differed between awake and anesthetized rats. Most MP values were checked after the end of urethral flow on the IUP curve, which is due to the peculiar methodology such as transvesical catheterization. Urethral flow was not completely interrupted during the IPHFOs, which suggests the presence of urethral wall tension against the flow during voiding. After removal of the superimposed effects of IAP from IVP, the DP curve clearly showed a peculiar shape, highlighting the possibility of using IAP in place of IUP to detect the flow starting point on the IVP curve. CONCLUSIONS: Awake rat cystometry results have been interpreted based on those in anesthetized rats. However, our awake cystometry data were substantially different in terms of voiding time compared to those of anesthetized rats. This discovery warrants careful interpretation of the voiding parameters in awake rat cystometry.


Sujets)
Animaux , Femelle , Humains , Rats , Cathétérisme , Cathéters , Rat Sprague-Dawley , Urètre , Vessie urinaire , Miction , Urodynamique
12.
International Neurourology Journal ; : 103-103, 2014.
Article Dans Anglais | WPRIM | ID: wpr-70864

Résumé

No abstract available.

13.
International Neurourology Journal ; : 162-167, 2013.
Article Dans Anglais | WPRIM | ID: wpr-166295

Résumé

PURPOSE: Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding. Various doses of methylphenidate were investigated for their effects on cystometric parameters in conscious mice. METHODS: Ten male C57BL/6 mice, weighing between 20 and 23 g, were used in this study. To compare the acute drug responses before and after the oral medication was administered in the awake condition, we injected the solution through a catheter inserted into the stomach. Methylphenidate (1.25, 2.5, and 5 mg/kg) in an injection volume of 0.05 mL was administered. RESULTS: Four mice that received high doses of methylphenidate (2.5 and 5 mg/kg) showed no voiding contraction, with urine leakage. Six mice that received a low dose of methylphenidate (1.25 mg/kg) showed typical micturition cycles before and after administration. The micturition pressure decreased and bladder capacity increased without an increased residual volume after administration. CONCLUSIONS: Methylphenidate has differential, dose-dependent effects on the function of the lower urinary tract, due to the dependent relationship between the brain and lower urinary tract. Especially at higher doses, this drug may interfere with normal micturition. Therefore, more detailed clinical or experimental studies are warranted in the future.


Sujets)
Animaux , Humains , Mâle , Souris , Trouble déficitaire de l'attention avec hyperactivité , Encéphale , Cathéters , Système nerveux central , Méthylphénidate , Volume résiduel , Estomac , Vessie urinaire , Vessie neurologique , Voies urinaires , Miction , Urodynamique
14.
International Neurourology Journal ; : 44-47, 2013.
Article Dans Anglais | WPRIM | ID: wpr-184787

Résumé

Rat cystometry is increasingly being used in research on overactive bladder and is a research tool for investigating bladder functions during the storage and voiding phases. Measurement of the pressure in the bladder is an essential part of cystometry, although that pressure is the sum of both detrusor and intra-abdominal pressures. In anesthetic cystometry, measurement of the intra-abdominal pressure is not necessary, because the values of this variable are negligible. In awake cystometry, however, it is mandatory to separate the changes in intra-abdominal pressure from those in intravesical pressure, because consciousness causes much variability in intra-abdominal pressure. This review describes why we use the term "detrusor overactivity" in animal research with intra-abdominal pressure and presents evidence for the role of intra-abdominal pressure in the cystometry of normal rats and in animal models of overactive bladder directed at understanding the pathogenesis of the overactive bladder condition. The methodology is also briefly reviewed.


Sujets)
Animaux , Rats , Expérimentation animale , Conscience , Modèles animaux , Vessie urinaire , Vessie hyperactive , Urodynamique
15.
International Neurourology Journal ; : 97-97, 2013.
Article Dans Anglais | WPRIM | ID: wpr-68529

Résumé

No abstract available.


Sujets)
Urodynamique
16.
International Neurourology Journal ; : 144-148, 2012.
Article Dans Anglais | WPRIM | ID: wpr-170970

Résumé

PURPOSE: Different techniques for cystocele repair including the conventional anterior colporrhaphy and mesh technique are known. Our goal was to evaluate the anatomical success and safety of our method of transvaginal anterior vaginal wall repair by the purse-string technique reinforced with three simple additional sutures in the repair of cystocele over a 4-year follow-up period. METHODS: This was a retrospective review of 69 consecutive patients (grades 2 to 4) who underwent the above operations between 2001 and 2011, including their success rates as assessed by use of the Baden-Walker halfway classification system. RESULTS: Of the patients, 62 patients (98%) were completely cured of cystocele and 1 patient showed grade 2 cystocele recurrence that required no further treatment. Two patients with grade 4 cystocele were completely cured. There was no vaginal erosion related to the cystocele repair. CONCLUSIONS: Transvaginal anterior colporrhaphy by a purse-string technique reinforced with simple additive sutures appears to be a simple, safe, and easily performed approach in cystocele repair. There is no need for other material for reinforcement, even in high-grade cystocele, which is an advantage of our technique.


Sujets)
Humains , Cystocèle , Études de suivi , Imidazoles , Composés nitrés , Prolapsus , Récidive , , Études rétrospectives , Matériaux de suture , Maladies de la vessie , Vagin
17.
International Neurourology Journal ; : 120-126, 2011.
Article Dans Anglais | WPRIM | ID: wpr-172515

Résumé

PURPOSE: We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the NVCs in these models. METHODS: A total of 20 female Sprague-Dawley rats were used in this study. In eight rats, chemical cystitis was induced by intravesical instillation of HCl. Twelve rats were subjected to sham instillations or partial BOO. Four weeks after intravesical instillation or 2 weeks after partial BOO, cystometrograms were obtained by use of simultaneous recording of intravesical and intraabdominal pressure in all unanesthetized, unrestrained rats in metabolic cages. RESULTS: A total of 17 rats survived. In the rats with acute injury by HCl, 50% showed detrusor overactivity (DO), which was not seen in the sham group. The cystitis group had lower DO pressure without a difference in DO frequency compared with the BOO group. After the administration of tolterodine, the cystitis group showed no difference in DO frequency or pressure, whereas the BOO group showed decreased values for both parameters. CONCLUSIONS: Our study showed that toleterodine produced no effect on DO during the filling phase in rats with chronic chemical cystitisbut decreased the frequency and pressure of DO in rats with BOO. Clinically, studies are needed to improve the treatment effect of anticholinergic drugs ininterstitial cystitis patients with overactive bladder.


Sujets)
Animaux , Femelle , Humains , Rats , Administration par voie vésicale , Composés benzhydryliques , Contrats , Crésols , Cystite , Phénylpropanolamine , Rat Sprague-Dawley , Salicylamides , Tartrate de toltérodine , Vessie urinaire , Obstruction du col de la vessie , Vessie hyperactive , Urodynamique
19.
Korean Journal of Urology ; : 835-841, 2011.
Article Dans Anglais | WPRIM | ID: wpr-187969

Résumé

PURPOSE: We investigated bladder function, with special focus on initial functional changes, by objective report of decompensated bladder according to the percentage of residual urine volume to bladder capacity in awake, obstructed rats. MATERIALS AND METHODS: Thirty rats were randomly subjected to sham operations (n=10) or partial bladder outlet obstruction (BOO, n=20). Cystometric investigations were performed without anesthesia 1 or 2 weeks after BOO surgery. To reduce the influence of confounding factors in awake cystometry, we used simultaneous recordings of intravesical and intraabdominal pressures. Decompensated bladder was defined as the bladder with more than 20% of residual volume compared with bladder capacity. RESULTS: Compared with that in sham animals, basal pressure was elevated in both BOO groups. Threshold pressure was higher in the 2 week BOO (p<0.01) group. Compliance was decreased in the 1 week BOO group (p<0.01) and increased in the 2 week BOO group (p<0.001). Bladder capacity was not increased in the 1 week BOO group, but was increased in the 2 week BOO group (p<0.01). Decompensation was found in 62.5% of the 1 week BOO group and in 33.3% of the 2 week BOO group. CONCLUSIONS: From the earlier phase, the bladders exhibited serial changes in pressure and volume parameters, and decompensated bladders defined by the percentage of residual volume to bladder capacity could be seen. During the later phase, there was an increasing tendency of compensated bladders, accompanied by the bladders being enlarged and more compliant.


Sujets)
Animaux , Rats , Anesthésie , Compliance , Volume résiduel , Salicylamides , Vessie urinaire , Obstruction du col de la vessie , Vessie hyperactive , Urodynamique
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