A Case of Sebaceous Trichofolliculoma / 대한피부과학회지

Sebaceous trichofolliculoma, which is a variant of trichofolliculoma, is a rare disease that clinically show a centrally depressed lesion usually singly on the nose, and histologically a centrally located cavity, lined by squamous epithelium, with numerous sebaceous lobules connected to them. We describe a case of sebaceous trichofolliculoma in a 27-year-old woman who had several brown papules on the nose. We think that this is the first report of sebaceous trichofolliculloma in Korean literature.

Clinical Study of 45 Cases of Sporotrichosis and Positive Rate According to Mycologic Method / 대한의진균학회지

BACKGROUND: Sporotrichosis is a chronic, deep cutaneous fungal infection characterized by nodular lesions of the cutaneous and subcutaneous tissues with involvement of the adjacent lymphatics. The infection is usually acquired by the traumatic implantation of the dimorphic fungus Sporothrix schenckii onto the skin. The incidence and cilnical features, treatment methods of sporotrichosis have been changed with time. OBJECTIVE: The purpose of this study is to describe the changes of the clinical features, diagnostic and treatment methods in sporotrichosis. METHODS: The observation of 45 patients with sporotrichosis who had visited the Department of Dermatology, Chonbuk National University Hospital for 18 years. All samples of formalin-fixed, paraffin- embedded skin tissue were stained with anti-BCG immunohistochemical stain and PAS stain. RESULTS: Forty-five cases of sporotrichosis were included. In the eighties, the first half (1982~1990), there were 28 cases (62%) of sporotrichosis, and there were 17 cases (38%) in the nineties, the second half (1991~1999). The age was varied from 4 to 82 years averaging 46 years and the sites of predilection were upper extremities (56%) and then the face (33%). The 64% of the total cases was lymphocutaneous type, and the rest was fixed cutaneous type. In the first half of the period the 32% was fixed cutaneous type, and in the second half of the period the 41% was fixed cutaneous type. The 42% of total cases was positive with PAS stain, and the 62% was positive with anti-BCG stain. In the treatment of sporotrichosis, potassium iodide (KI) was the choice of treatment in the first half of the period, however itraconazole is gradually used in the second half of the period. CONCLUSION: According to this study, some changes in clinical findings and treatment methods of sporotrichosis were noted. Anti-BCG stain can be the useful screening method.

Tick bite: Report of a Case and Review of Korean Cases / 대한피부과학회지

We report a case of a tick bite by Ixodes nipponensis found on the neck of a 75-year-old female. The tick was thought to be in the lesion for 10 days. Till now 31 cases of tick bites were reported in Korea including the present case. The review of the Korean cases revealed that the ratio of female/male was 1.3 : 1, its age distribution was from 1st to 8th decade, sites of the invasion were trunk, head and neck, extremities, and anogenital area in order of frequency. Its prevalent season was spring and summer and the most common species(17/31) was Ixodes nipponensis.

A Case of Merkel Cell Carcinoma with Spontaneous Regression / 대한피부과학회지

Merkel cell carcinoma is a rapidly growing malignant neuroendocrine tumor with a high rate of recurrence and metastasis for which wide excision is recommended. About 10 cases of spontaneous regression have been reported in the world. We report a case of Merkel cell carcinoma which showed spontaneous regression. The patient was a 68-year-old woman with a two-month history of a rapidly enlarging dusky red tumor on her right cheek. Microscopically, the tumor cells were uniform with round to oval shaped nucleus and scanty cytoplasm, and showed trabecular arrangement. Ultrastructually, dense core neurosecretory granules 100 to 200nm in diameter were found in the cytoplasm of tumor cells. As far as we know, this is the first case of the spontaneous regression of the tumor in the country.

A Case of Chloracne Due to Exposure to Defoliating Agent During Vietnam war / 대한피부과학회지

Chloracne is a refractory acneiform eruption due to halogenated polyaromatic compound(eg. dioxin, dibenzofurans, polychlorinated biphenyls, etc.). 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, a kind of dioxin isomer, contained in the Agent Orange which was used for defoliating agent during Vietnam war. It is characterized by recalcitrant comedones and cyst predominantly in the malar and postauricular area. Lesions of the penis and scrotum are also relatively frequent. The key pathological feature is the non-inflammatory keratinization of pilosebaceous unit. The meibomian glands are typically affected. Xerosis, conjunctivitis, pigmentation, follicular hyperkeratosis, actinic elastosis are occasionally associated with chloracne. We report a case of typical chloracne due to exposure to defoliating agent during Vietnam war in a 54-year-old-man who shows typical clinical and histopathological features.

A Case of Epidermolysis Bullosa Acquisita (Cicatricial pemphigoid-like type) / 대한피부과학회지

Epidermolysis bullosa acquisita (EBA) is an uncommon autoimmune subepidermal blistering disorder and has four clinical subtypes. Among the four types of EBA, the cicatricial pemphigoid-like type is rarer than the other types and clinically the worst one. We experienced a case of cicatricial pemphigoid-like type of EBA in a 69-year-old woman, whose initial symptom was painful erosive lesions of oral mucous membrane before development of ocular and bullous cutaneous lesions. The clinical, histopathological findings and immunoblot assay were all typical of the disease. The course of her disease showed remissions by treatments including corticosteroid and intravenous immunoglobulin, but each time with exacerbations.