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Rev. méd. Chile ; 143(2): 213-222, feb. 2015. graf, tab
Article Dans Espagnol | LILACS | ID: lil-742573

Résumé

Background: The Quality of life Bipolar Disorder (QoL.BD) Questionnaire specifically measures quality of life in patients with bipolar disorder. Aim: To adapt a version translated into Spanish of the questionnaire and assess its validity in Chilean patients. Material and Methods: The QoL. BD was adapted to the Chilean population through the back-translation method and then administered to 32 adult patients with a bipolar disorder and 31 subjects without the disease, both groups with similar socioeconomic status. To confirm the diagnosis, the International Neuropsychiatric Interview (MINI), Young (YMRS) and Hamilton (HAM-D) scales were applied. Quality of life was assessed using the SF-36v.2 survey. We determined internal consistency, reliability, convergent validity, the cut-off point, and the sensibility and specificity of the scale. Results: The Chilean version of the Questionnaire [QoL. BD-CL] had a high reliability (α = 0.95) and a high validity in reference to external criteria (correlation coefficients with SF-36 ranging from 0.453 and 0.819; p < 0.01). A cut-off point of 170, with sensitivity of 87.9% and specificity of 80% was determined. Conclusions: QoL.BD-CL has adequate psychometric properties, as well as an adequate sensitivity and specificity to distinguish between negative and positive perceptions of life quality in Chilean patients with bipolar disorders.


Sujets)
Animaux , Souris , Poly(ADP-ribose) polymerases/métabolisme , Mort cellulaire/génétique , Mort cellulaire/physiologie , Altération de l'ADN/génétique , Altération de l'ADN/physiologie , Embryon de mammifère/métabolisme , Génotype , Méthode TUNEL , Souris knockout , Poly(ADP-ribose) polymerases/déficit , Poly(ADP-ribose) polymerases/génétique , Réaction de polymérisation en chaîne
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