Comparison of usefulness of percutaneous coronary intervention guided by angiography plus computed tomography versus angiography alone and its impact on instent restenosis

Background: Optimal stent selection and placement would be expected to improve clinical outcomes. Coronary computed tomography angiography [CCTA] may permit better preprocedural planning

Objectives: To assess the impact of incorporating coronary computed tomography angiogaphy guidance in defining reference value for stent length and diameter on angiographic and clinical outcomes in comparison to quantitative coronary angiography and its effect on incidence of instent restenosis

Methods: The study was conducted on 153 diabetic patients with stable coronary artery disease. Patients were divided into two groups: group A and group B according to PCI guidance either with quantitative computed tomography angiography [QCTA] datasets or quantitative computed tomography [QCA] datasets respectively. Follow up clinically for six months to assess incidence of major adverse cardiac events [MACE] and angiographically by coronary angiography at six months or before if clinically indicated to assess incidence of instent restenosis [primary end point]

Results: QCTA was associated with longer lesions [p=0.001] and larger reference vessel diameter [p=0.001] than that measured by invasive QCA in group A. No statistical significant difference between group A and group B regarding restenosis rate, minimum lumen diameter at follow up and incidence of MACE

Conclusions: CCTA guided percutaneous coronary intervention [PCI] is a safe and effective strategy for treatment of coronary artery disease however it didn't add a beneficial role in reducing incidence of instent restenosis or MACE in comparison to angiographic guidance alone

Comparative study for induction of painless labor between bupivacaine 0.25%, bupivacaine-fentanyl and clonidine-fentanyl

Labor analgesia is better provided by the epidural administration of local anesthetics with adjuvants e.g Opioids and alpha agonist to reduce local anesthetic requirements and side effects [e.g] systemic toxicity and motor blockade. 60 pregnant women subjected to: Action; Group I; Group II; Group III-Onset of analgesia; 20 Min; 17 Min; 26. Min-Duration of analgesia; 57 Min; 72 Min -; 57 Min-Motor Weakness; Sever; Moderate; Mild-Hemodynamic changes; Mild; Mild; Mild. From the previous study we concluded that the addition of adjuvants to local anesthetics in epidural labor analgesia is better than local anesthetics alone as regard complication and obstetric intervention