Résumé
Our experimental study showed that in a dose related manner SP has successful inhibitory effect on the rat uterine horn, and also on the smooth muscle organs; ileum and trachea. We guess that SP can be used in well regulated dosed with least side effects to arrest preterm labor on human being in the future. Up to date there is no manuscript about contraction inhibitory effect of SP on the uterus. We hope this study will be of scientific help.
Sujets)
Animaux , Diéthylstilbestrol/pharmacologie , Relation dose-effet des médicaments , Femelle , Iléum/effets des médicaments et des substances chimiques , Isoxsuprine/administration et posologie , Contraction musculaire/effets des médicaments et des substances chimiques , Rats , Lignées consanguines de rats , Ritodrine/administration et posologie , Spironolactone/administration et posologie , Trachée/effets des médicaments et des substances chimiques , Contraction utérine/effets des médicaments et des substances chimiquesRésumé
The spontaneous contractions of the rabbit uterine horns and the human myometrial strips were stimulated by oxytocin and buserelin acetate in isolated preparations. Spironolactone application to these models produced inhibitory effects on the contractions. It is concluded that spironolactone has inhibitory effect on the rabbit uterine horn and the human myometrial strip contractions.