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Mem. Inst. Oswaldo Cruz ; 104(4): 621-625, July 2009. tab
Article Dans Anglais | LILACS | ID: lil-523730

Résumé

Significant advances were made in the diagnosis of filariasis in the 1990s with the emergence of three new alternative tools: ultrasound and tests to detect circulating antigen using two monoclonal antibodies, Og4C3 and AD12-ICT-card. This study aimed to identify which of these methods is the most sensitive for diagnosis of infection. A total of 256 individuals, all male and carrying microfilariae (1-15,679 MF/mL), diagnosed by nocturnal venous blood samples, were tested by all three techniques. The tests for circulating filarial antigen concurred 100 percent and correctly identified 246/256 (96.69 percent) of the positive individuals, while ultrasound detected only 186/256 (73.44 percent). Of the circulating antigen tests, ICT-card was the most convenient method for identification of Wuchereria bancrofti carriers. It was easy to perform, practical and quick.


Sujets)
Adolescent , Adulte , Sujet âgé , Animaux , Enfant , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Anticorps antihelminthe , Anticorps monoclonaux , Antigènes d'helminthe/sang , Filariose lymphatique/diagnostic , Microfilaria/ultrastructure , Wuchereria bancrofti/immunologie , Test ELISA , Filariose lymphatique/sang , Filariose lymphatique , Sensibilité et spécificité , Jeune adulte
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