1.
Indian J Exp Biol
;
1990 May; 28(5): 486-7
Article
Dans Anglais
| IMSEAR
| ID: sea-57642
Résumé
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.
Sujets)
Alcaloïdes , Animaux , Benzodioxoles , Synergie des médicaments , Hypnotiques et sédatifs , Mâle , Microsomes du foie/effets des médicaments et des substances chimiques , Pentobarbital/administration et posologie , Pipéridines/administration et posologie , Amides gras polyinsaturés N-alkylés , Rats , Sommeil/effets des médicaments et des substances chimiques
2.
Hindustan Antibiot Bull
;
1984 Aug-Nov; 26(3-4): 138-9
Article
Dans Anglais
| IMSEAR
| ID: sea-2274
3.
Hindustan Antibiot Bull
;
1981 ; 23(): 6-11
Article
Dans Anglais
| IMSEAR
| ID: sea-2631