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1.
Article Dans Anglais | WPRIM | ID: wpr-982294

Résumé

Chinese medicine (CM) is an important resource for human life understanding and discovery of drugs. However, due to the unclear pharmacological mechanism caused by unclear target, research and international promotion of many active components have made little progress in the past decades of years. CM is mainly composed of multi-ingredients with multi-targets. The identification of targets of multiple active components and the weight analysis of multiple targets in a specific pathological environment, that is, the determination of the most important target is the main obstacle to the mechanism clarification and thus hinders its internationalization. In this review, the main approach to target identification and network pharmacology were summarized. And BIBm (Bayesian inference modeling), a powerful method for drug target identification and key pathway determination was introduced. We aim to provide a new scientific basis and ideas for the development and international promotion of new drugs based on CM.


Sujets)
Humains , Médecine traditionnelle chinoise , Médicaments issus de plantes chinoises/usage thérapeutique , Théorème de Bayes , Simulation de docking moléculaire
2.
Article Dans Chinois | WPRIM | ID: wpr-1015736

Résumé

Mast cells are one of the major immune cells in the human body and best known for their role in allergy and anaphylaxis. The main structural characteristic of mast cells is that they contain a large number of basophilic granules, and the basophilic granules are rich in a variety of bioactive substances including histamine, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), matrix metalloproteinase (MMP), tryptase, chymase and a diverse number of inflammatory mediators. Histamine is involved in the proliferation, migration and invasion of some kinds of cancer cells, and VEGF, FGF, MMP, tryptase and chymotryptase play a significant role in different stages of tumor angiogenesis. The release of various inflammatory mediators from mast cells can lead to inflammatory response at the site of tumor formation, and it is well known that chronic inflammation is a primary risk factor for cancer development and progression. Some studies have shown that a significantly increased number of mast cells can be detected in different tumor tissues. The active substances released by mastcells can stimulate tumor growth, tumor angiogenesis and promote tumor metastasis. Furthermore, the tumor microenvironment also plays an important role in regulating the recruitment of mast cells to tumor tissues and the maturation and activation of mast cells. In this article, we will review the latest progress in the effects of mast cells on tumor growth, tumor angiogenesis, and tumor microenvironment on mast cellactivation.

3.
Chinese Pharmacological Bulletin ; (12): 1047-1053, 2021.
Article Dans Chinois | WPRIM | ID: wpr-1014479

Résumé

Famesyltransferase, a membrane-associated protein, catalyzes the addition of the 15-carbon fragment of famesyl diphosphate to the cysteine SH group of the CAAX motif containing protein substrates to regulate the function of target proteins through famesylation. As one of the most important target proteins of FTase, oncogenic forms of Ras mutants have been reportedly involved in more than 30% human cancers, and are known to play critical roles in cancer development and progression. Despite decades of research, Ras inhibitors are so elusive that no therapeutic agents directly targeting Ras mutants have been clinically approved, the primary reason for which is the lack of druggable pockets on the surface of Ras. Therefore, FTase, the main regulator of Ras protein, has gradually become a research hotspot, and many FTase inhibitors have been developed, synthesized and used for the treatment of malignant tumors. In the present review, we briefly describe the regulation of Ras functions by FTase and the role of FTase in cancers, and mainly explore the research progress of FTase inhibitors as a promising strategy for cancer therapy.

4.
Acta Physiologica Sinica ; (6): 565-570, 2018.
Article Dans Chinois | WPRIM | ID: wpr-687794

Résumé

Son of sevenless homolog 1 (SOS1) protein is a ubiquitously expressed adapter. As a key protein in intracellular signaling, SOS1 plays an important role in many signal transduction pathways, such as Ras and Rac signaling pathways. The abnormal expression or mutation of SOS1 is closely related to clinical diseases. In this article, we review research progress on SOS1 functions and its roles in physiology and pathophysiology.

5.
Acta Physiologica Sinica ; (6): 57-64, 2016.
Article Dans Chinois | WPRIM | ID: wpr-331682

Résumé

Gab proteins, Grb2 (growth factor receptor binding protein 2)-associated binder, are important scaffolding adapter proteins required by many signaling pathways. In mammals, the Gab proteins mainly consist of Gab1, Gab2 and Gab3, and are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including various growth factors and cytokines. They are known to play key roles in many biological processes through the two classical signal pathways, SHP2/RAS/ERK and PI3K/AKT. In this review, we provide an overview of the structure and function of the scaffolding adapter, Gab, with a special focus on its role in tumor, inflammation and cardiovascular diseases.


Sujets)
Humains , Protéines adaptatrices de la transduction du signal , Maladies cardiovasculaires , Inflammation , Protéines et peptides de signalisation intercellulaire , Tumeurs , Phosphatidylinositol 3-kinases , Phosphorylation , Transduction du signal
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