Résumé
Com o objetivo de avaliar o efeito do flavonóide naringenina e do carotenóide bixina associado com o leite em pó de cabra sobre o metabolismo lipídico foi realizado um experimento com coelhos da raça Nova Zelândia por um período de 31 dias. Foram coletadas amostras de sangue e o soro obtido foi utilizado para a determinação de colesterol total, colesterol-HDL e triacilgliceróis. As duas substâncias associdas com o leite reduziram as concentrações de colesterol, sendo o melhor resultado obtido com o grupo leite de cabra + naringenina no 16º dia e 31º dia. Em relação às concentrações de triacilgliceróis o grupo leite de cabra + naringenina apresentou o melhor resultado, tendo uma redução significativa no 16º dia e 31º dia. Para o colesterol-HDL, todos os grupos apresentaram bons resultados, aumentando as concentrações desse parâmetro, tendo destaque o grupo leite de cabra + bixina no16º dia e 31º dia.
Sujets)
Animaux , Lapins , Cholestérol HDL , Caroténoïdes/pharmacologie , Flavonoïdes/pharmacologie , Lipides , Lait , Triglycéride/sang , Hypolipémiants/pharmacologie , Cholestérol/sang , Modèles animaux de maladie humaine , Capra , Hyperlipidémies , Peroxydation lipidiqueRésumé
The objective of this research was to evaluate in rabbits the effect of different dosages rutin in seric levels of chloride, calcium and phosphoro. Rabbits of New Zealand strain aged 55 days of age were used. The animals were divides in males and females, being constituted 4 groups by sex, containing each one 5 animals, that received rutin in the dosages of 20, 40 and 60 mg. The controls groups received only the ration. Samples of blood were collected by retro-orbital vein plexo puncture being then centrifuged at 3500 x g for 15 minutes and serum measurement determined in a multiparametric doage of biochemistry (Alizé). For chloride results it was observed that rutin in the tested doses were significant for males although the variations were not considered toxic. It was also observed that the males presented significant values in dosis of 20 mg of rutin when compared with the females. Being analyzed the medium sanguine values of match and being compared males and female, significant differences were verified with the group that received 20 mg of rutin. Whith relatonship at the levels of calcium, this didn´t present significant alterations when we compared male and females. The females submitted to 20 mg rutin presented altered calcium levels, however those alterations did not present omportant physiologic significance once the other doses didn´t act in significant variations in the levels of calcium. It is concluded that the presented variations were not considered toxic for the parameters chloride, calcium and match in the blood of rabbits.