Protein loss during isolated ultrafiltration patients with chronic renal failure

Six hypertensive overhydrated maintenance dialysis patients [4 women, 2 men] were treated with isolated ultrafiltration and sequential dialysis for 1 to 3 months. Two to 5.5 liters of fluid were removed each time in 2-4 hours of isolated ultrafiltration. Haemoglobin concentration and haematocrit increased in proportion to the volume of fluid extracted. Serum protein concentration increased to a lesser extent indicating protein loss during ultrafiltration. The ultrafiltrate contained 0.432 +/- 0.084 g/Liter of immunognobulins. The proportion of filtered IgA relative to its plasma concentration was highest and that of IgG lowest, probably due to differences in the shapes of their molecules

Predialytic isolated ultrafiltration in overhydrated patients on maintenance hemodialysis

Six hypertensive grossly overhydrated maintenance dialysis patients [2 men, 4 women] were treated with sequential ultrafiltration-haemodialysis for 1-3 months. Two to 5.5litres of fluid were removed in 2-4 hours of isolated ultrafiltration. During it, blood pressure was relatively stable, pulse rate slightly decreased and patients did not experience headache, vomiting or faintness. Dyspnoea and signs of pulmonary oedema subsided, There was no significant change in serum sodium, potassium and urea while serum creatinine slightly increased. In about 4 weeks oedema disappeared in all patients and blood pressure came down to normal in four. A distinct rise in serum creatinine was noticed in 3 patients after 3 months