Résumé
Background & objectives: Microalbuminuria has been described as an early sign of vascular damage in certain high risk goups such as diabetes, hypertension & family history of cardiovascular renal disease. In diabetes mellitus the prognostic value of microalbuminuria as a marker of early nephropathy and increased cardiovascular risk has been well established. The aim of this study is to establish the prevalence of microalbuminuria in nondiabetic essential hypertensive patients and its relation with target organ damage. Material and Methods: 100 non diabetic essential hypertensive patients attending OPD as well as admitted in the tertiary care hospital of Jamnagar were included in this study. They underwent detailed clinical examination. A single early morning urine sample was used to measure microalbuminuria by Micral test strip and urine creatinine was measured to establish albumin creatinine ratio. Results: The age of patients selected for study varied from 35 to 76 years; mean age being 51.5 years. 52% were males and mean duration of hypertension was 3.9 +/- 3.9 yrs. Microalbuminuria was found in 46% of the patients and showed significant association with male gender (p=0.001), age (p<0.05) & target organ damage in any form (p<0.05). Interpretation and conclusion: Measuring urinary albumin excretion (UAE), a simple, low cost and readily available test, can be regarded as a cost effective way to identify nondiabetic essential hypertensives at high risk and can thus help to prevent the development of complications by aggressive treatment to get down to target blood pressure.