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Braz. j. med. biol. res ; 29(11): 1567-71, Nov. 1996. ilus, tab
Article Dans Anglais | LILACS | ID: lil-187222

Résumé

We investigated the effect of intratesticularly injected propranolol on testicular interstitial fluid (TIF) formation and on testosterone levels in the TIF of intact adult male Wistar rats (4-9 rats per group). D1-propranolol at doses of 0.6, 1.2 or 6.0 mg/kg was injected into the left (L) testis whereas the right (R) testis (control testis) received vehicle. d1-propranolol (6.0 mg/kg) caused a significant increase in both TIF volume (329 per cent) and TIF levels of testosterone (257 per cent) in the L testis but not in the R (control) testis 3 h post-injection. In rats treated simultaneously with human chorionic gonadotropin (hCG, 5 IU/rat, sc) the same dose of propranolol (6.0 mg/kg) significantly increased the stimulatory effect of hCG on testosterone secretion by 1.8-fold, but hCG did not modify the stimulatory effect of propranolol on TIF volume. These results demonstrate a direct stimulatory effect of propranolol on TIF volume and testosterone secretion, both under basal and hCG-stimulated conditions.


Sujets)
Rats , Animaux , Mâle , Gonadotrophine chorionique/pharmacologie , Cellules de Leydig/effets des médicaments et des substances chimiques , Propranolol/pharmacologie , Testostérone/métabolisme , Espace extracellulaire/effets des médicaments et des substances chimiques , Rat Wistar
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