Glutathione and malondialdehyde levels in patients with hydatid cyst

To investigate the levels of glutathione [GSH], and malondialdehide [MDA] in the sera of patients diagnosed with cyst hydatid. Forty-six hydatid cyst patients who were indirect hemaglutination [IHA] and indirect fluorescence antibody [IFA] test positive constituted our study group in 2007. Patients diagnosed with hydatid cyst in the Inonu University School of Medicine, Department of Parasitology were re-called for the study. Forty healthy subjects who were negative for hydatid cyst by IHA and IFA methods, and who did not have any parasites on stool inspection formed the control group. The MDA level was analyzed in the sera by Uchiyama and Mihara method. The GSH activity was measured by the Ellman method. The GSH level was 11.31 -/+ 3.80 umol/L and the MDA level was 67.94 -/+ 106.70 umol/L in the study group, while they were 24.95 -/+ 6.55 umol/L and 26.52 -/+ 19.42 umol/L in the control group. An increase in MDA levels and a decrease in GSH activity in patients with hydatid cyst was observed

Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 +/- 543.8 in optical density (mean +/- SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.