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China Journal of Chinese Materia Medica ; (24): 913-915, 2005.
Article Dans Chinois | WPRIM | ID: wpr-358057

Résumé

<p><b>OBJECTIVE</b>To observe the protective effect of Panax notoginseng saponins (PNS) on the level of synaptophysin ptotein in brain in rat model with Alzheimer's disease (AD).</p><p><b>METHOD</b>The AD rat models were established by intra-peritoneal injection of D-galactose combined with excitatory neurotoxin ibotenic acid injection into bilateral nbM. The activity and content of synaptophysin protein in brain were determined by immunohistochemistry analysis.</p><p><b>RESULT</b>PNS could reduce the lesion of level of synaptophysin protein in brain, as compared with those of model group's rats.</p><p><b>CONCLUSION</b>PNS plays a protective role by reducing down of the level of synaptophysin protein in brain in lesion of AD animal model.</p>


Sujets)
Animaux , Rats , Maladie d'Alzheimer , Métabolisme , Anatomopathologie , Noyau basal de Meynert , Anatomopathologie , Encéphale , Métabolisme , Anatomopathologie , Galactose , Toxicité , Ginsénosides , Pharmacologie , Acide iboténique , Toxicité , Neuroprotecteurs , Pharmacologie , Panax , Chimie , Plantes médicinales , Chimie , Rat Wistar , Synaptophysine , Métabolisme
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