Résumé
Poonaga parpam (PNP) is an animal origin siddha formulation mentioned in the Siddha text “Sikicha Rathina Deepam”. The trial drug was prepared as per the standard operative procedure and subjected to various studies to reveal its potency. Materials and methods: The aim of the study was to standardize the PNP by modern instrumental techniques such as Fourier Transform Infra-Red Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectroscopy (ICPOES), Scanning Electron Microscope with Energy Dispersive X-Ray Analysis (SEM with EDAX), X-Ray Diffractometer (XRD), Thermo Gravimetric Analysis (TGA). Results and Discussion: ICP-OES revealed the heavy metals like As, Cd, Pb, Hg and trace element like Ni were below detectable level. The stretches and bonds present in the FTIR analysis indicated the presence of some organic functional groups such as alcohol, aromatic, alkane, carbonyl, ketone, alkane, amine and alkyl halide which may be the reason for the therapeutic potency of the drug. XRD results revealed that the copper and iron may be the key ingredients present in the test drug PNP and the SEM picture indicated the existence of nanoparticles. TGA results revealed that the test drug PNP seems to be stable at varying temperature ranges from 50 to 400°C. Based on the results, Poonaga Parpam is preferably non-toxic to human in its therapeutic dose.
Résumé
Objective: The present pilot study was designed to evaluate the efficacy of Seenthil sarkarai, a Classical Siddha medicine in Moothirakiricharam (Urinary Tract Infection) patients. Method: This study was approved by IEC and registered in Clinical Trial Registry of India and was conducted at the National Institute of Siddha, Tambaram, Chennai, India. The investigator recruited 20 patients of both male and female with an inclusion and exclusion criteria. All the patients were treated with Seenthil Sarkarai at the dose level of 2 grams two times a day with warm water for 21 days. Dietary regimen was advised for the patients. Study outcome was studied with negative Urine culture and also based on the improvement in the reduction of Burning micturition, Frequency of micturition, Dysuria with fever, Foul smelling urine. Results: The symptoms such as burning micturition, persistent urge to urinate, foul smelling urine, and presence of bacteriuria reduced markedly within 21 days of duration. Out of 20 patients, 12 patients were completely relieved from the compliance of UTI with negative Urine culture. The symptoms of UTI were markedly reduced in remaining 8 patients. There were no adverse effect reported during the study and no recurrence of UTI was noticed in 12 patients who were completely cured. Conclusion: Results suggest that the trial drug Seenthil Sarkarai is effective and safe for the management of Moothirakiricharam (UTI) and in alleviating recurrences.