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Gamme d'année
1.
Braz. j. med. biol. res ; 52(5): e8233, 2019. tab
Article Dans Anglais | LILACS | ID: biblio-1001522

Résumé

Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups: non-smoker COPD group (n=16) with exposure to biomass smoke who did not smoke cigarette and tobacco smoker COPD group (n=15) with people who did not report biomass smoke exposure. Subjects underwent pulmonary function tests, thoracic high-resolution computed tomography, 6-min walk test, and sputum induction. The non-smoker COPD group had biomass smoke exposure of 133.3±86 hour-years. The tobacco COPD group smoked 48.5±27.4 pack-years. Women were 62.5 and 66.7%, respectively, of non-smokers and smokers. The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity. Regarding inflammatory biomarkers, differences were detected in sputum number of lymphomononuclear cells and in sputum concentrations of interleukin (IL)-6 and IL-8 with higher values in the smoker group. Emphysema was more prevalent in the tobacco smoker group, which also showed higher relative bronchial wall thickness and lower lung density by quantitative analysis. Biomass smoke induced more hypoxemia compared to tobacco in COPD patients with similar severity.


Sujets)
Humains , Mâle , Femelle , Adulte d'âge moyen , Sujet âgé , Fumée/effets indésirables , Nicotiana/effets indésirables , Biomasse , Broncho-pneumopathie chronique obstructive/imagerie diagnostique , Hypoxie/imagerie diagnostique , Tests de la fonction respiratoire , Spirométrie , Expectoration/composition chimique , Tomodensitométrie , Études transversales , Broncho-pneumopathie chronique obstructive/étiologie , Exposition environnementale , Hypoxie/étiologie
2.
Braz. j. med. biol. res ; 51(12): e7558, 2018. tab
Article Dans Anglais | LILACS | ID: biblio-974253

Résumé

The association between pet ownership and the development of allergic and respiratory diseases has been the aim of several studies, however, the effects of exposure in adults remain uncertain. The aims of the present study were to investigate the prevalence of asthma and lung function status among dog and cat owners. This cross-sectional study was performed at two universities with students and workers who were allocated into 3 groups according to pet ownership in the previous year: cat owners, dog owners, and no pets (control group). Subjects underwent spirometry, bronchial challenge test with mannitol, skin prick tests, and questionnaires about animal exposures and respiratory symptoms. Control group comprised 125 subjects; cat owner group, 51 subjects; and dog owner group, 140 subjects. Cat owners had increased asthma prevalence (defined by symptoms and positive bronchial challenge test), but no changes in lung function compared to the control group. The dog owner group had lower spirometry values (forced expiratory volume in one second and lower forced vital capacity), but similar asthma prevalence, compared to the control group. In the cat owner group, excess of asthma may have an immunological basis, since we found an association with atopy. Although we did not have endotoxin data from volunteers' households, we postulated that low values of lung function were associated to exposure to endotoxins present in environments exposed to dogs.


Sujets)
Humains , Animaux , Mâle , Femelle , Enfant , Adolescent , Adulte , Chats , Chiens , Jeune adulte , Propriété/statistiques et données numériques , Asthme/étiologie , Asthme/épidémiologie , Animaux de compagnie , Poumon/physiopathologie , Valeurs de référence , Hypersensibilité respiratoire/épidémiologie , Asthme/physiopathologie , Spirométrie , Brésil/épidémiologie , Allergènes/effets indésirables , Volume expiratoire maximal par seconde/physiologie , Prévalence , Études transversales , Facteurs de risque , Analyse de variance , Exposition environnementale/effets indésirables
3.
Braz. j. med. biol. res ; 41(3): 209-214, Mar. 2008. ilus, tab
Article Dans Anglais | LILACS | ID: lil-476578

Résumé

Inhalation of hypertonic saline (HS) causes bronchoconstriction in asthmatic subjects. Repeated inhalation of HS leads to substantially reduced bronchoconstriction, known as the refractory period. Refractoriness due to different stimuli has also been described (cross-refractoriness). Nocturnal asthma is defined as an increase in symptoms, need for medication, airway responsiveness, and/or worsening of lung function that usually occurs from 4 to 6 am. Our objective was to determine the effect of refractoriness on nocturnal asthma. The challenge test consisted of inhalations of 4.5 percent saline with increasing durations until a reduction of 20 percent in forced expiratory volume in 1 s (FEV1) (PD20HS) or total time of 15.5 min. Twelve subjects with nocturnal asthma were challenged with HS at 16:00 and 18:00 h and FEV1 was measured at 4:00 h. One to 2 weeks later, FEV1 was determined at 16:00 and 4:00 h. LogPD20HS at 18:00 h was significantly greater than logPD20HS at 16:00 h, 0.51 ± 0.50 and 0.69 ± 0.60 mg, respectively (P = 0.0033). When subjects underwent two HS challenges in the afternoon, mean (± SD) FEV1 reduction was 206 ± 414 mL or 9.81 ± 17.42 percent. On the control day (without challenge in the afternoon) FEV1 reduction was 523 ± 308 mL or 22.75 ± 15.40 percent (P = 0.021). Baseline FEV1 values did not differ significantly between the control and study days, 2.48 ± 0.62 and 2.36 ± 0.46 L, respectively. The refractory period following HS challenges reduces the nocturnal worsening of asthma. This new concept may provide beneficial applications to asthmatic patients.


Sujets)
Adulte , Femelle , Humains , Mâle , Asthme/prévention et contrôle , Tests de provocation bronchique/méthodes , Solution saline hypertonique/administration et posologie , Administration par inhalation , Rythme circadien , Volume expiratoire maximal par seconde , Débit expiratoire de pointe
4.
Braz. j. med. biol. res ; 39(1): 71-78, Jan. 2006. tab, graf
Article Dans Anglais | LILACS | ID: lil-419154

Résumé

Fitness improvement was used to compare morning with afternoon exercise periods for asthmatic children. Children with persistent moderate asthma (according to GINA criteria), 8 to 11 years old, were divided into 3 groups: morning training group (N = 23), afternoon training group (N = 23), and non-training group (N = 23). The program was based on twice a week 90-min sessions for 4 months. We measured the 9-min running distance, resting heart rate and abdominal muscle strength (sit-up number) before and after the training. All children took budesonide, 400 æg/day, and an on demand inhaled ß-agonist. The distance covered in 9 min increased (mean ± SEM) from 1344 ± 30 m by 248 ± 30 m for the morning group, from 1327 ± 30 m by 162 ± 20 m for the afternoon group, and from 1310 ± 20 m by 2 ± 20 m for the control group (P < 0.05 for the comparison of morning and afternoon groups with the control group by ANOVA and P > 0.05 for morning with afternoon comparison). The reduction of resting heart rate from 83 ± 1, 85 ± 2 and 86 ± 1 bpm was 5.1 ± 0.8 bpm in the morning group, 4.4 ± 0.8 bpm in the afternoon group, and -0.2 ± 0.7 bpm in the control group (P > 0.05 for morning with afternoon comparison and P < 0.05 versus control). The number of sit-ups in the morning, afternoon and control groups increased from 22.0 ± 1.7, 24.3 ± 1.4 and 23 ± 1.1 sit-ups by 9.8 ± 0.9, 7.7 ± 1.4, and 1.9 ± 0.7 sit-ups, respectively (P > 0.05 for morning with afternoon comparison and P < 0.05 versus control). No statistically significant differences were detected between the morning and afternoon groups in terms of physical training of asthmatic children.


Sujets)
Humains , Mâle , Femelle , Enfant , Asthme/rééducation et réadaptation , Bronchodilatateurs/usage thérapeutique , Rythme circadien/physiologie , Traitement par les exercices physiques/méthodes , Analyse de variance , Muscles abdominaux/physiologie , Salbutamol/usage thérapeutique , Asthme/traitement médicamenteux , Budésonide/usage thérapeutique , Études cas-témoins , Association thérapeutique , Rythme cardiaque/physiologie , Études prospectives , Tests de la fonction respiratoire , Indice de gravité de la maladie
5.
Braz. j. med. biol. res ; 36(3): 291-299, Mar. 2003. tab, graf
Article Dans Anglais | LILACS | ID: lil-329457

Résumé

This prospective study analyzed the involvement of the autonomic nervous system in pulmonary and cardiac function by evaluating cardiovascular reflex and its correlation with pulmonary function abnormalities of type 2 diabetic patients. Diabetic patients (N = 17) and healthy subjects (N = 17) were evaluated by 1) pulmonary function tests including spirometry, He-dilution method, N2 washout test, and specific airway conductance (SGaw) determined by plethysmography before and after aerosol administration of atropine sulfate, and 2) autonomic cardiovascular activity by the passive tilting test and the magnitude of respiratory sinus arrhythmia (RSA). Basal heart rate was higher in the diabetic group (87.8 ± 11.2 bpm; mean ± SD) than in the control group (72.9 ± 7.8 bpm, P<0.05). The increase of heart rate at 5 s of tilting was 11.8 ± 6.5 bpm in diabetic patients and 17.6 ± 6.2 bpm in the control group (P<0.05). Systemic arterial pressure and RSA analysis did not reveal significant differences between groups. Diabetes intragroup analysis revealed two behaviors: 10 patients with close to normal findings and 7 with significant abnormalities in terms of RSA, with the latter subgroup presenting one or more abnormalities in other tests and clear evidence of cardiovascular autonomic dysfunction. End-expiratory flows were significantly lower in diabetic patients than in the control group (P<0.05). Pulmonary function tests before and after atropine administration demonstrated comparable responses by both groups. Type 2 diabetic patients have cardiac autonomic dysfunction that is not associated with bronchomotor tone alterations, probably reflecting a less severe impairment than that of type 1 diabetes mellitus. Yet, a reduction of end-expiratory flow was detected


Sujets)
Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Système nerveux autonome , Diabète de type 2 , Cardiopathies , Études cas-témoins , Rythme cardiaque , Tonus musculaire , Études prospectives , Tests de la fonction respiratoire
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