Quality of life of leprosy patients in Sabah

@#Objective: To determine the Dermatology Life Quality Index (DLQI) among the subtypes of leprosy and to examine correlation with deformity and lepra reactions. Methods: This was a cross-sectional study done at Dermatology Outpatient Clinic, Queen Elizabeth Hospital and two health clinics in Kota Kinabalu between 1st April 2019 and 30th November 2019. A standardised case report form was formulated to collect the demographic data and disease profile of the leprosy patients. The quality of life (QoL) was assessed using Dermatology Life Quality Index (DLQI) questionnaire. Results: A total of 54 patients were included with a male to female ratio of 2.4:1 (38 males and 16 females). The mean DLQI score was 8.31±6.15. The difference between the mean DLQI scores among the leprosy subtypes was not significant. The most affected domain was symptoms and feeling followed by daily activities and leisure. Twenty-one patients (38.9%) had facial deformity and they were found to have significantly higher DLQI score. WHO grade 1 and 2 disability were observed in 37 patients (68.5%) with higher DLQI score compared to those without any disability. More than half of patients with MB leprosy (52.2%) developed lepra reactions but the difference of mean DLQI scores were not significant. Conclusions: Leprosy-related disabilities may predispose patients to develop psychosocial problems which may have negative impact on QoL. Thus, periodic assessment of QoL should be incorporated into the management of leprosy patients

Patch Testing With Preservative Sensitizers. A Year Retrospective Study From Selayang Hospital

Abstract Introduction: Other than nickel, fragrance and rubber, preservatives are well known sensitizers. Objectives: To study the pattern of preservative allergy among patients patch tested at Patch Test Unit Selayang Hospital. Materials & Methods: We conducted a retrospective analysis of the data of all the patients patch tested with preservative sensitizers present in the European Baseline Series and other commercial series in Selayang Hospital from January 2011 to December 2011. Results: 243 patients were patch tested. 28.4% of the patients had a positive reaction to one or more of the preservative sensitizers. Paraben mix was the most frequently positive allergen (11.8%). 17.8% of the Indians had paraben allergy, as compared to 11.3% of Malays and 11.2% of Chinese. Females were more significantly associated with a positive reaction to one or more of the preservative sensitizers (p=0.010). A younger age group (<35) was more significantly associated with formaldehyde allergy. “Face and upper limbs combined” presentation was significantly associated with a positive reaction to formaldehyde and methylchloroisothiazolinone/ methylisothiazolinone (p=0.042 and p<0.001 respectively). Conclusion: Our data differ from most other countries in that paraben mix was the most frequently positive preservative sensitizer and that younger age group was significantly associated with sensitization to formaldehyde.