Synthesis of N, N'-bis [N-4-N-methylcarbamyl-oxymethylthioxanthen-9-on-1-yI aminoethyI] piperazine of possible antitumor activity

N,N'-bis [N-[4-hydroxymethylthioxanthen-9-on-1-yl] piperazine and its N-methylcarbamate derivative have been synthesized. The compounds are considered a combination of two molecules of the antischistosomal drug, hycanthone. The two compounds are possibly active as antitumor as well as antischistosomal

Synthesis of some substituted 4-hydroxymethyl benzofuryl-5-propenoic acid lactone

Xanthotoxin [8-methoxy psoralene] [1], a drug currently used for the treatment of leukodermia, has been the subject of several workers for more than 9decades due to its pharmacological and chemical interest [1-5] It has been previously shown that when 4-hydroxymethylxanthotoxin was subjected to methylation by dimethyl sulphate in alkaline medium gave the cyclized product 6 7-dimethoxy-4-hydroxymethyl-5-benzofurylpropenoic acid lactone [4][6]. Similar structure analogue in which the lactone oxygen [1'], is substituted by sulfer, was obtained by cleavage methylation of the corresponding 4-thioguanidinyl methyl derivative [7]. Structure elucidation of both cyclized products was based on their 1H NMR spectra

Measurement of relative basicity of 1-oxa-2, 2-disubstituted 2-silacycloalkanes by IR spectroscopy

In a previous communication we have reported the synthesis of some alpha trimethylsiloxy - w-methyl [ethoxy] silyl Substituted alkanes I as well as their conversion into 1-oxa-2,2 disubstituted-2-silacycloalkanes II