Research progress on the pathogenesis and treatment of Enterococcus faecalis in pulp periapical disease / 口腔疾病防治

@#Enterococcus faecalis is an important pathogen in pulp periapical disease that has been widely studied in recent years. A large number of studies have shown that the high detection rate of Enterococcus faecalis in root canals with persistent or secondary infection after root canal therapy is closely related to the failure of root canal therapy. The presence of Enterococcus faecalis in periapical pulp disease is related to its pathogenicity and virulence factors. Enterococcus faecalis can directly invade host tissues or induce immune inflammation in host tissues, resulting in periapical pulp tissue damage and lesions. Enterococcus faecalis has a strong tolerance to conventional root canal antibiotics and disinfection methods and is difficult to completely remove from the complex root canal system. How to fight Enterococcus faecalis infection has become an important direction in the treatment of pulp periapical disease. This article reviews the pathogenic mechanism of Enterococcus faecalis infection in pulp periapical disease and the progress in its treatment.

Relationship between T cells and bone regeneration: recent progress and perspectives / 口腔疾病防治

@#Bone is capable of regeneration after injury, but the process of properly restoring form and function is highly complex and prone to failure. The restoration process requires highly ordered and sequential interplay at the injury site between the host immune system and bone tissue. The dynamic process that occurs after bone injury includes the formation of a hematoma, the development of an inflammatory response and callus, and the remodeling of newly formed bone tissue. The inflammatory response at the injury site is essential for the onset of bone regeneration. This inflammatory response is tightly linked with the host immune system, in which various immune cells and molecules are involved. Recently, the relationship between T cells and bone regeneration has become a popular topic; however, currently, there are no summaries of the relationship between T cells and bone regeneration. Thus, this review aimed to elucidate the modulatory functions of T cells in bone regeneration.