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1.
Braz. j. med. biol. res ; 22(11): 1421-9, 1989. ilus
Article Dans Anglais | LILACS | ID: lil-83149

Résumé

Freshly dispersed testicular interstitial cells as well as Percoll-purified Leydig cells were studied in vitro in order to evaluate the effect of adrenergic agonists on testosterone (T) secretion. Epinephrine and phenylephrine did not change the rate of T release under basal conditions in freshly dispersed interstitial cells, but enhanced it during human chorionic gonadotropin (hCG) stimulation. Norepinephrine and clonidine had no effect on T secretion. In contrast, in Percoll-purified Leydig cells epinephrine increased T release both under basal and hCG-stimulated conditions. These data demonstrate that neurotransmitters may participate in T secretion from isolated Leydig cells


Sujets)
Rats , Animaux , Mâle , Cellules de Leydig/physiologie , Épinéphrine/pharmacologie , Techniques in vitro , Phényléphrine/pharmacologie , Testostérone/métabolisme , Cellules cultivées , Clonidine/pharmacologie , Norépinéphrine/pharmacologie , Lignées consanguines de rats
2.
Braz. j. med. biol. res ; 21(3): 539-43, Mar. 1988. ilus
Article Dans Anglais | LILACS | ID: lil-60249

Résumé

Percoll-purified Leydig cells were studied in vitro in order to evaluate the effect of adrenaline on testosterone (T) secretion. Adrenaline enhanced the basal and potentiated the hCG-induced T release. A similar effect was also obtained with the ß2-agonist, salbutamol. Although phenyleprine, an alfa1-agonist, did not alter the basal T secretion, it enhanced hCG-mediated T secretion. Para-aminoclonidine, an alfa2-agonist, decreased the basal T release without altering the HCG-stimulated T release. These data demonstrate that either inhibitory or stimulatory effects on T release can be obtained and that they depend on the adrenoreceptor subtype involved


Sujets)
Rats , Animaux , Mâle , Gonadotrophine chorionique/pharmacologie , Épinéphrine/pharmacologie , Techniques in vitro , Cellules de Leydig/biosynthèse , Récepteurs adrénergiques/pharmacologie , Testostérone/métabolisme , Lignées consanguines de rats , Testostérone/métabolisme
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