Résumé
Present study was conducted to see the effect of potassium channel blockers, 4-aminopyridin [4-AP], Tetraethylammoniumchloride [TEA[+]C1] and Quininehydrochloride on morphine induced analgesia in rats. Charles Foster albino rats [either sex] weighing between 100-200 gm were selected and divided into four groups of six each. Group I was selected as control and treated with 'normal saline, Group II was treated with 4-AP, Group III was treated with TEA [+] Cl and Group IV was given Quinine hydrochloride. After treatment with potassium channel blockers analgesia was induced in all groups by giving morphine sulphate and reaction time to pain was noted in seconds. The mean reaction time was reduced in all the three groups as compared to the control group. This effect could be attributed to the effect of potassium channel blockade on the release of neurotransmitters