Résumé
For the study on the effect of retinoic acid on the formation of palatal rugae and the cleft palate, retinoic acid was administered orally 150mg/kg of body weight by gastric tube at GD 10.5 to Sprague-Dawley rats. The pregnant rats were sacrificed on GD 17.5 under ether anesthesia, and laparatomized. After removal of uterus, the number of pregnant sacs and fetuses were counted. The fetuses weighed, the MEE (medial edge epithelium) thickness measured and the mitotic figures counted after routine processing and H·E stain. All the palates were photographed, and the number of rugae & the rugal pattern analysed. TEM photographs of MEE cells were observed after routine processing. The results were as follows ; 1. Rat fetus body weight after retinoic acid treatment increased significantly compared with the control group. 2. Mitotic figures in the retinoic acid treated group increased significantly compared with control group. 3. In the retinoic acid treated group, 79.3% of fetuses had cleft palates. Among fetuses with cleft palates, complete cleft palates were 10.6%, incomplete cleft palate 89.4%. Incomplete clefts were of two types ; median type (cleft palate at the intermolar region) and soft palate type (cleft posterior to the 8th rugae). Median type was 64.6% and the soft palate type 35.4%. 4. 2.3% of the fetuses had the numerical anomaly of the palatal rugae in the control group, but that of retinoic acid treated group 87.7%. 5. 17.4% of palatal rugae of the control group was disrupted, but 100% of the retinoic acid treated group disrupted. 6. Rugal papillae were observed in the 15.1% of fetuses of the control group and 63.1% of fetuses of the retinoic acid treated group. 7. Longitudinal rugae were observed in 19% of fetuses of the retinoic acid treated group, but not in the control group. 8. In TEM photographs, cytoplasmic processes, intercellular space, and desmosomes decreased. Swelling of mitochondria & ER were also found in the retinoic acid treated groups. According to the above results, it appears that there is close relationship between palatal rugae and cleft palates, and that excess retinoic acid induces disruption of pattern and numerical variations of rat fetus palate rugae. Also retinoic acid has an inhibitory effect on the proliferation of medial edge epithelial cells of palatal shelves. The cleft palates may be induced by the above mentioned retinoic acid effects. But, the exact mechanisms of retinoic acid on cleft palate formation is not thoroughly known and should be further studied.
Sujets)
Animaux , Rats , Anesthésie , Poids , Fente palatine , Cytoplasme , Desmosomes , Cellules épithéliales , Oxyde de diéthyle , Espace extracellulaire , Foetus , Mitochondries , Palais , Palais mou , Rat Sprague-Dawley , Trétinoïne , UtérusRésumé
The ankle is a complex structure supporting the entire musculoskeletal system during standing and walking. The injuries to the ankle joint result in a severe functional disturbance because of complex anatomical characteristics around the ankle joint. 284 patients of the ankle fracture that were treated in orthopedic Dept. Capital Armed Forced General Hospital from march 1985. to march 1988. were analized in clinical and radiological aspects. The following results were obtained: 1. The main cause of the injuries was falling from a height and the other were sports injury and slipping down in order. 2. The most common type by Lauge-Hansen classification was supination-external rotation type(122 case, 42.9%). 3. 211 case(74.3%) were treated with open reduction and internal fixation, and 73 case(25.7%) were treated with closed reduction. Poor outcome seemed closely related to the severity of the injury and degree of fracture displacement. 4. Accurate reduction and rigid internal fixation of the lateral malleolus with shortening was important factor. 5. Classification of Lauge-Hansen was useful in the diagnosis and treatment of the ankle fractures.
Sujets)
Humains , Chutes accidentelles , Fractures de la cheville , Articulation talocrurale , Cheville , Bras , Traumatismes sportifs , Classification , Étude clinique , Diagnostic , Hôpitaux généraux , Appareil locomoteur , Orthopédie , Marche à piedRésumé
The hindfoot in the human body is known to play an important function for weight bearng, shock absorption and locomotion. The defect of hindfoot presents serious problems of the leg length discrepancy and weight bearing. Therefore, it is essential to reconstruct the defect of hindfoot. Up to date, many surgical modalities from a skin graft to the innervated osteocutaneous flap have been developed, but a completely satisfactory method of reconstruction has not been found. The ideal reconstructive method should provide sufficient padding tissue and sensibility. In the Department of Orthopaedic Surgery, capital Armed Forces General Hospital, two cases of hindfoot defect due to explosion were reconstructed by the midplantar fasciocutaneous flap with free iliac bone graft. The results of our procedure were very acceptable one year after the operations.
Sujets)
Absorption , Bras , Explosions , Hôpitaux généraux , Corps humain , Jambe , Locomotion , Méthodes , Choc , Peau , Transplants , Mise en charge , Plaies et blessuresRésumé
A total of 188 cases of primary bone tumor was reviewed and analyzed clinically and pathologically at the Department of Orthopaedic Surgery, Presbyterian Medical Center, Jeonju, Korea during the 10 years period from January, 1970 to December, 1979. The results were obtained as follows: 1. 58 cases were benign and 130 cases were malignant. 2. Osteochondroma was the most common benign bone tumor and followed by giant cell tumor, simple bone cyst, osteoma and fibrous dysplasia. 3. Giant cell tumor was 15 cases, which were divided pathologically into benign(Grade I & II) 8 cases and malignant (Grade III) 7 cases. and treated by curretage, curettage & bone graft, arthrodesis, irradiation and amputation. 4. The most common primary malignant bone tumor was osteosarcoma, and it was followed by chondrosarcoma, fibrosarcoma and multiple myeloma. 5. Osteosarcoma was 60 cases and it occured commoly around knee joint area. 6. Treatment of primary malignant bone tumor contained of amputation, chemotherapy and irradiation.
Sujets)
Amputation chirurgicale , Arthrodèse , Kystes osseux , Chondrosarcome , Curetage , Traitement médicamenteux , Fibrosarcome , Tumeurs à cellules géantes , Articulation du genou , Corée , Myélome multiple , Ostéochondrome , Ostéome , Ostéosarcome , Protestantisme , TransplantsRésumé
30 cases of distal femur fracture were treated with cast-brace for 2 years and 6 months from Feb., 1977 till July, 1979 at the department of Orthopaedic Surgery, Presbyterian Medical Center, in Jeon Ju. The results were obtained as follows: 1. In 9 cases, cast-brace were applied initially and other 21 cases were treated with cast-brace secondarily after operation. 2. 20 cases were male and 10 cases were female. 3. 12 cases were on mid 1/3 fracture and 18 cases were distal 1/3 fracture involving 2 condylar fractures. 4. The average duration of fracture healing was 14.7 weeks in the cases with cast-brace which is compared with 20.7 weeks of hip-spica cast control group. 5. A.G.F. of knee joint was 80–115 degree at removal of cast-brace, otherwise merely 50–65 degree at dlscarding of hip-spica cast. 6. There were no complication such as nonunion or delayed union in the cases with cast-brace.