Effect of Helicobacter pylori eradication on childhood acute idiopathic thrombocytopenic purpura / 南方医科大学学报

<p><b>OBJECTIVE</b>To evaluate the effect of Helicobacter pylor (Hp) eradication in children with acute idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>Ninety-three children with acute ITP and Hp infection were divided into two groups and treated with prednisone and Hp eradication (group A, 51 cases) or with prednisone without Hp eradication (group B, 42 cases).</p><p><b>RESULTS</b>The Hp eradication rate was 94.1% in group A. No difference was found in the therapeutic effects on IPT between the two groups, but the recurrence rate in one year in group A was significantly lower than that in group B.</p><p><b>CONCLUSION</b>NHp eradication does not obviously enhance the therapeutic effect on childhood acute ITP, but can decrease the relapse rate in one year. HP eradication therapy is recommended in children with acute ITP and Hp infection.</p>

Features of ischemic myocardial contracture after asphyxia-induced cardiac arrest in rats / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the features of ischemic myocardial contracture after asphyxial cardiac arrest in rats.</p><p><b>METHOD</b>Asphyxial cardiac arrest was induced in 8 Wistar rats, and the length and width of the heart were measured at the different time points after cardiac arrest.</p><p><b>RESULTS</b>Obvious ischemic myocardial contracture occurred after the cardiac arrest, reaching the maximal contracture at 4-6 min after the arrest.</p><p><b>CONCLUSIONS</b>Ischemic myocardial contracture induced by asphyxia may be an important factor affecting the outcome of cardiopulmonary resuscitation.</p>

Changes in cyclooxygenase gene expression during spontaneous recovery from stress ulcer in rats / 南方医科大学学报

<p><b>OBJECTIVE</b>To observe the changes in gene expression of cyclooxygenase (COX) during spontaneous recovery from stress ulcer in rats exposed to water immersion and restraint stress (WRS).</p><p><b>METHODS</b>A rat model of stress ulcer was established by means of WRS, in which the changes in COX expression were detected with immunohistochemistry and reverse transcription (RT)-PCR.</p><p><b>RESULTS</b>Very low levels of COX-2 expression were detected in the gastric mucosa of the control rats, and the expression increased significantly during the healing process of the stress ulcer (P<0.05). COX-1 expression in the gastric mucosa showed no significant difference between the control group and the stress ulcer groups during healing (P>0.05).</p><p><b>CONCLUSION</b>COX-1 and COX-2 expressions in rat gastric mucosa during the recovery from stress ulcer participate in the recovery of the damaged mucosa possibly by mediating prostaglandin secretion.</p>