Résumé
A large number of studies have demonstrated that mRNA vaccine has been characterized as a technique with good safety, strong immunogenicity and high developmental potential, which makes it have broad prospects in immunotherapy. In recent years, the stability and in vivo delivery efficiency of mRNA vaccines have been largely addressed by the progresses in mRNA engineering and delivery innovation. And some mRNA vaccines are now clinical approved or in preclinical trials. Here, we summarize current knowledge on the research advances, technology, and application in major infectious diseases in humans and animals of mRNA vaccines, with the aim to provide a reference for improving the development of novel mRNA vaccines.
Sujets)
Animaux , Humains , Maladies transmissibles , Vaccins synthétiques/génétique , Vaccins à ARNmRésumé
<p><b>OBJECTIVE</b>Building a method which can examines virus pathogenic in gastroenteritis excrement specimen.</p><p><b>METHODS</b>Choosing six positive specimens which tested in our laboratory, include adenovirus, calicivirus, rotavirus, bocavirus, astrovirus and enterovirus. Through sequence-independent single primer amplification(SISPA) constructs a gene bank. Looks up the viral gene fragment in gene bank.</p><p><b>RESULTS</b>Obtaining corresponding viral acid sequence in six specimens.</p><p><b>CONCLUSION</b>This research can examine enterovirus and the virus which cause diarrhea, It make a foundation for further studies the viral cause of disease which the examination not yet discovered at present.</p>