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Article Dans Chinois | WPRIM | ID: wpr-298701

Résumé

<p><b>OBJECTIVE</b>To assess the therapeutic effect of losartan on type 2 diabetes mellitus (DM2) with gas chromatography (GC)-based metabonomics.</p><p><b>METHODS</b>DM2 patients were dosed with losartan (100 mg/d) and urines were collected at week 8 and 12. The biochemical criteria (blood pressure, urinary albumen, urinary 8-hydroxy-2'-deoxyguanosine and blood creatinine) were analyzed. Urine samples were derivatived and analyzed by GC. Multivariate metabonomics analysis was performed after peak alignment.</p><p><b>RESULTS</b>After 8-12 weeks, losartan showed little curative effect and no remarked changes of biochemical criteria were observed. However, metabonomics analysis revealed that some biomarkers such as glucitol and inositol changed.</p><p><b>CONCLUSION</b>GC-based metabonomics analysis enables the rapid identification of metabolic differences and provides information concerning therapeutic effect of losartan.</p>


Sujets)
Humains , Albuminurie , Urine , Marqueurs biologiques , Sang , Chimie , Urine , Chromatographie en phase gazeuse , Méthodes , Créatinine , Sang , Désoxyguanosine , Urine , Diabète , Traitement médicamenteux , Diabète de type 2 , Traitement médicamenteux , Surveillance des médicaments , Hypoglycémiants , Utilisations thérapeutiques , Inositol , Chimie , Losartan , Utilisations thérapeutiques , Métabolome , Sorbitol , Chimie
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