Clinical effect of rosuvastatin on unstable angina and the influence on serum lipids, hs-CRP, Hcy and cTnl / 中国生化药物杂志

Objective To explore the clinical effect of rosuvastatin in treatment of unstable angina and the influence of levels on blood lipids,hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy)and cardiac troponin(cTnl).Methods 200 patients with unstable angina pectoris(UAP)in our hospital from March 2014 to March 2016 were selected as the subjects of the study,they were randomly divided into control group and experimental group,each group had 100 cases.The control group was given conventional treatment,the experimental group was given rosuvastatin on the basis of conventional treatment,the clinical efficacy between two groups was observed and compared,and the levels of blood lipid and C reactive protein(hs-CRP),homocysteine(Hcy)troponin I(cTnl)pre-and post-treatment were detected.Results The total effective rate of the experimental group was 92％and the control group was 80％,the difference was statistically significant(P<0.05).Before treatment,the blood lipid,hs-CRP,Hcy and cTnl between two groups showed no significant difference; after treatment,the blood lipid,hs-CRP,Hcy and cTnl in both two groups were decreased,high density lipoprotein cholesterol(HDL-C)levels than before treatment significantly increased,and the experimental group decreased or increased significantly compared with the control group,the difference was statistically significant(P<0.05).Conclusion Rosuvastatin has remarkable curative effect in clinical treatment for UAP,not only can significantly reduce the blood lipid,and reduce inflammation in patients,the clinical treatment of unstable angina patients have help,it is worthy of clinical application.

The expression of TLR4 in patients with ACS undergoing selective percutaneous coronary intervention and the effect of atorvastatin on it / 中国生化药物杂志

Objective To analyzethe expression level of peripheral blood mononuclear cell Toll like receptor 4(TLR4)in patients with acute coronary syndrome(ACS)undergoing elective percutaneous coronary intervention(PCI),and intensive atorvastatin on Toll like receptor 4 in clinical treatment.Methods 100 cases of patients with ACS were selected in our hospital from May 2014 to May 2016 were randomly divided into control group and experimental group,control group were given atorvastatin treatment after admission,20mg/d PCI postoperative continuous,after one month still maintain dose of 20mg/d.The experimental group were given atorvastatin treatment after admission,40mg/d,PCI postoperative continuous,after one month reduced to 20mg/d.After admission and a course of treatment,the expression level of peripheral blood mononuclear cells TLR4 was detected by flow cytometry and the Gensini scoring system on coronary lesion degree.At the same time,50 healthy subjects were selected as normal group.Results Compared with healthy subjects,the peripheral blood mononuclear cells TLR4 level in ACS patients has been significantly increased,and the level in patients with unstable angina pectoris is far lower than the level increased in patients with acute myocardial infarction,triple branch lesions groups were significantly higher than them in single and double branch lesion groups,the difference between the three obviously,with statistical significance(P<0.01); According to stepwise multiple linear regression and othercorrelation analysis showed that ACS category and the severity of coronary artery stenosis,coronary artery stenosis score were positively associated with the levels of TLR4(P<0.05); After treatment for one month,the levels of TLR4,the expression of low density lipoprotein cholesterol and total cholesterol levels were significantly lower,high density lipoprotein Cholesterol levels were significantly increased,the differences were statistically significant(P<0.01); compared with the normal group,the experimental group peripheral blood mononuclear cells of patients with Toll like receptor 4 expression level,total cholesterol,low density lipoprotein cholesterol level in the experimental group is higher than the normal group,high density lipoprotein cholesterol increased significantly,comparison between groups the differences were statistically significant(P<0.01).Conclusion The degree of lesions and the occurrence of acute coronary syndrome in patients with peripheral blood mononuclear cells of Toll like receptor 4 expression level increase has certain effect,increase the dosage of atorvastatin can significantly reduce the ACS after PCI in patients with peripheral blood mononuclear cells of patients with Toll4 like receptor expression.