Résumé
Objective To investigate the prevalence of depression in children with type 1 diabetes (T1DM) and analysis its risk factors. Methods A total of 225 children with T1DM were divided into 2 groups according to BDI score:T1DM+depression group (n=123,BDI>10) and T1DM group (n=102,BDI≤10).Then,the subjects in T1DM+depression group were divided into mild depression subgroup (n=42,102 times/d were higher in T1DM+depression group than in T1DM group(P2 times/d were higher in severe depression subgroup than in mild subgroup and medium subgroup,DM course and ratio of insulin injection≤2 times/d were lower in severe depression subgroup than in mild subgroup (P2 times/d were the influencing factors for BDI levels.Logistic regression analysis showed that girl,long DM course,insulin injection>2 times/d,high HbA1c,high incidence of DKA and hypoglycemia were risk factors for depression in T1DM children (P<0.05). Conclusion The higher occurrence of depression in T1DM children indicates that early screening and intervention is necessary.Children with risk factors should be given more psychological care to prevent the occurrence of depression.
Résumé
Objective To observe Rongxin Pills in the treatment of viral myocarditis in children (deficiency of both qi and yin and heart meridian stasis syndrome) and the effectiveness and clinical application of safety.Methods Viral myocarditis patients (280 cases,deficiency of both qi and yin and heart meridian stasis syndrome),according to 3:1 ratio as the test group (n =21 0) and control group (n =70).The test group took orally Rongxin pills each time 4.5～9 g,3 times daily;the control group oral coenzyme Q10 capsule each time 10 ～ 20 mg,twice daily.The course of treatment was 28 d.The experiment was carried out with the random and double blind method.The symptoms of myocarditis,integrated and electrocardiogram,echocardiography,myocardial enzymes,as well as the efficacy of traditional Chinese medicine and improvement of the effect of the disease were observed.Results The results of FAS (PPS) analysis showed that 28 d after treatment,the symptom score and mean of experimental group and control group were 5.975 (6.000) and 4.721 (4.788).The syndromes of the total effective rates were 91.62％ (90.59％) and 70.59％ (71.21％),curative effect the total effective rates were 90.14％ (92.08％) and 72.06％ (72.73％).The total effective rate of experimental group was higher than that of the control group,the difference was statistically significant.In this experiment,three cases of clinical adverse events were reported,which were not related to the experimental drug.It also not belongs to adverse drug reactions.Conclusion Rongxin Pill in the treatment of viral myocarditis in children (deficiency of both qi and yin and heart meridian stasis syndrome) is more effective than coenzyme Q 10 capsule,and there was no indication of higher risk of clinical application.
Résumé
Objective To explore the influence of long-term inhaled corticosteroids on insulin-like growth factor-1(IGF-1),bone mineral density, height and weight in children with bronchial asthma.Methods Bronchial asthma were selected as treatment group from January 2013 to January 2014 in pediatrics department of Nanyang Central Hospital, and 25 healthy children undergoing physical examination at the same time were selected as control group.All children aged from 4 to 5 years old.The treatment group received nebulized budesonide suspension, 250-1 000μg per time, two times per day and 10-15 min per time for a maintenance therapy of 12 months.The control group were without any treatment.The changes of IGF-1 and bone mineral density were compared among pre-treatment, 6 months and 12 months post-treatment in treatment group and the changes of height and weight were compared between two groups.Results There were no significant differences in levels of serum IGF-1 and bone mineral density among pre-treatment, 6 months and 12 months post-treatment in treatment group (F =0.259,F =0.217, all P>0.05).There were no significant differences in height and weight between two groups pre-treatment, 6 months and 12 months post-treatment.Conclusion Long-term inhaled corticosteroids has no significant effect on growth indicators in children aged 4-5 years old with bronchial asthma.