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1.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 155-160, 2022.
Article Dans Anglais | WPRIM | ID: wpr-929246

Résumé

Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1.


Sujets)
Animaux , Souris , Médicaments issus de plantes chinoises/composition chimique , Structure moléculaire , Rosmarinus , Triterpènes/composition chimique
2.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 22-26, 2019.
Article Dans Anglais | WPRIM | ID: wpr-776909

Résumé

Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC of 2.6 and 3.8 μmol·L, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.


Sujets)
Animaux , Humains , Souris , Lignée cellulaire tumorale , Survie cellulaire , Cirsium , Chimie , Oxyde de diéthyle , Chimie , Macrophages , Métabolisme , Structure moléculaire , Extraits de plantes , Chimie , Pharmacologie , Plantes comestibles , Chimie , Plantes médicinales , Chimie , Triterpènes , Chimie , Pharmacologie , Facteur de nécrose tumorale alpha , Métabolisme
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