Effect of ranolazine on the fast sodium channel current in rabbit atrial myocytes and use-dependent blockade / 西安交通大学学报(医学版)

Objective To explore the effect of ranolazine on the fast sodium channel current (INa) in rabbit atrial myocytes and the existence of use-dependent blockade. Methods Standard whole cell patch clamp technique was used to study the effect of ranolazine on the fast sodium channel current and the use-dependent blockade caused with different frequencies (1Hz, 3.3Hz and 5Hz) to stimulate the cells. Results The 30μmol/L ranolazine significantly reduced INa with an IC_(50) value of (25.6±1.8)μmmol/L and produced a frequency-dependent inhibitory effect on INa with obvious use-dependence. Conclusion Ranolazine can inhibit the fast sodium channel current in rabbit atrial myocytes and indeed has a use-dependent effect.

Experience of transradial coronary angiography in 304 patients / 中国介入心脏病学杂志

Objective To evaluate the feasibility, safty and methology of transradial coronary angiography Methods Transradial coronary angiography was carried out in 304 patients Results Transradial coronary angiography and ventriculography were successful in 291 patients (95 7%) Conclusion Radial artery seems to be both feasible and safe for coronary angiography, with a very low risk of local complication and more comfort for patients