Study on Cytotoxicity of Codeine Phosphate Tablets / 中国药师

Objective:To compare the formula of codeine phosphate tablets produced by two enterprises. Methods: IC50 of the tablets and raw material of codeine phosphate, and the excipients from two enterprises was detected respectively. Results:IC50 of the tablets from A enterprise was 0. 169 mg·ml-1 , that from B enterprise was 0. 140 mg·ml-1 , and the difference was statistically sig-nificant(P0. 05). Conclusion: The difference in cytotoxicity of codeine phosphate tablets is manly induced by the excipients, and the products from A enterprise are better than those from B enterprise.