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1.
Journal of Zhejiang University. Science. B ; (12): 203-210, 2009.
Article Dans Anglais | WPRIM | ID: wpr-335380

Résumé

Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the beta-adrenergic receptor (beta-AR). In the present study, we investigated NET and beta1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and beta1-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.


Sujets)
Animaux , Mâle , Rats , Vieillissement , Physiologie , Régulation de l'expression des gènes , Génétique , Myocarde , Métabolisme , Transporteurs de la norépinéphrine , Génétique , Métabolisme , ARN messager , Génétique , Rat Sprague-Dawley , Récepteurs bêta-1 adrénergiques , Métabolisme
2.
Chinese Journal of Physical Medicine and Rehabilitation ; (12)2003.
Article Dans Chinois | WPRIM | ID: wpr-683278

Résumé

0.05).After treatment,in neuromus- cular electric stimulation therapy group and ice-massage therapy group,SSA scores and degrade of SaO_2 were improved. There was significant difference between before and after treatment(P

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