1.
China Pharmacy
; (12)2007.
Article
de Chinois
| WPRIM
| ID: wpr-529696
RÉSUMÉ
OBJECTIVE:To establish a HPLC method for the simultaneously determination of three components in Bikeling nasal spray. METHODS: The column we used was Hypersil ODS and the mobile phase was 0.1%mtriethylamine(adjust pH3.2 with phosphate acid)-acetonitrile (75∶25). The detective wavelength was 256nm and the sample size was 10?L. RESULTS: The linear rangs of ofloxacin, ephedrine hydrochloride and dexamethasone sodium phosphate were 32~320?g?mL-1(r=0.999 9),64~640?g?mL-1(r=1.000 0) and 4~40?g?mL-1(r=1.000 0)respectively, and the average recoveries were 100.05%(RSD=0.32%), 100.17%(RSD=0.48%) and 99.85%(RSD=1.67%),respectively. CONCLUSION: The method was simple and accurate and can be used for the quality control of Bikeling nasal spray