Expression of C-X-C chemokine receptor type 7 in otorhinolaryngologic neoplasms

<p><b>INTRODUCTION</b>C-X-C chemokine receptor type 7 (CXCR7) has recently been characterised as a novel receptor for the C-X-C motif chemokine 12 (CXCL12)/stromal cell-derived factor 1-alpha. CXCR7 has been thought to play an important role in the pathogenesis of chronic rhinosinusitis, angiogenesis and tumour metastasis. The present study aimed to examine the expression of CXCR7 in tissue samples of laryngeal cancer and maxillary sinus carcinoma to determine its role in the development of otorhinolaryngologic neoplasms.</p><p><b>METHODS</b>Samples of otorhinolaryngologic neoplasms were obtained from 17 patients with either nasal polyps (n = 7), laryngeal cancer (n = 5) or maxillary sinus carcinoma (n = 5), and who underwent surgical resection at West China Hospital of Sichuan University. Total RNA was isolated and CXCR7 mRNA expression was examined and quantified by relative real-time reverse transcription polymerase chain reaction. A one-way analysis of variance was performed using SPSS Statistics version 11.0 (SPSS Inc, Chicago, IL, USA) to compare the CXCR7 mRNA levels among the three groups of patients.</p><p><b>RESULTS</b>All samples tested positive for CXCR7 mRNA. The quantitative results showed that the CXCR7 mRNA levels were highest in laryngeal cancer and lowest in maxillary sinus carcinoma neoplasms, although there was no significant difference among the three samples.</p><p><b>CONCLUSION</b>CXCL12 and its receptor CXCR7 may contribute to eosinophilic inflammation in patients with chronic sinusitis and nasal polyps. Our results also suggest that CXCR7 may play a role in the progression, metastasis and angiogenesis of otorhinolaryngologic tumours.</p>

Expression of serum tumor necrosis factor-аlpha and interleukin-1beta in a vascular dementia rat model undergoing total flavonoids of hippophae / 中国组织工程研究

BACKGROUND:Total flavonoids of hippophae have different degrees of regulation effect on the immune system. However, there is no available evidence addressing the effect of total flavonoids of hippophae on vascular dementia inflammatory factor. OBJECTIVE:To observe the effect of total flavonoids of hippophae on serum tumor necrosis factor-αand interleukin-1βlevels in a rat model of vascular dementia, and to discuss its interventional mechanism for vascular dementia. METHODS:A total of 72 Wistar rats were randomly divided into six groups:sham operation, model, control, high-dose, medium-dose, and low-dose of total flavonoids of hippophae groups. Except for the sham operation group, rats in the other five groups were applied to establish vascular dementia models using the improved“vascular occlusion”method. Sham operation group was only subjected to the isolation of bilateral common carotid artery, without ligation. At 1 day after modeling, rats in control group was intragastrical y given Ginkgo biloba extracts 48 mg/kg?d, while rats in total flavonoids of hippophae groups were given 200, 100, 50 mg/kg?d of total flavonoids of hippophae. Model group and sham operation group received equal volume of saline. After 30 days of administration, rats were detected in Morris water maze. Serum tumor necrosis factor-αand interleukin-1βlevels of rats in different groups were detected after intervention. RESULTS AND CONCLUSION:Compared with sham operation group, the vascular dementia model rats had a disordered learning and memory ability, and increased levels of serum tumor necrosis factor-αand interleukin-1β(P<0.05). After intervention of Ginkgo biloba extracts and total flavonoids of hippophae, the learning and memory abilities were improved, and serum tumor necrosis factor-αand interleukin-1βlevels were decreased (P<0.05). Total flavonoids of hippophae can reduce serum tumor necrosis factor-αand interleukin-1βlevels in vascular dementia rats. This may be the main mechanism of treating vascular dementia.

Chronic invasive fungal rhinosinusitis complicated with infratemporal fossa fungal infection: 2 cases report / 临床耳鼻咽喉头颈外科杂志

Two cases of chronic invasive fungal rhinosinusitis were reported. One patient healed while another died with suspicious residual fungal infection. The clinical symptoms of infratemporal fungal infection include maxillofacial pain, with or without fever. Acute or chronic inflammation of soft tissue could be revealed pathologically. Proof of pathogen may not be found in histopathological slice while serological detection may reveal positive evidence. Surgical resection, good drainage and postoperative antifungal therapy could cure or promptly relieve the symptoms of the disease.

Resection of anterior skull base cranio-nasal communication tumors via the inner plate of frontal sinus-epidural approach / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the application of inner plate of frontal sinus-epidural approach in the treatment of anterior skull base cranio-nasal communication tumors.@*METHOD@#A study of 6 cranio-nasal communication tumor patients was undertaken. They were treated with lateral rhinotomy-inner plate of frontal sinus-epidural approach to remove tumor.@*RESULT@#The tumors in all the 6 patients were completely resected. The follow-up study during the following 2 years revealed that 5 patients had good facial appearances and showed no tumor recurrence, no cerebrospinal rhinorrhea, no meningoencephalocele, no frontal collapse, and other complications.@*CONCLUSION@#The surgical approach in the treatment of Cranio-nasal communication tumors needs to be chosen according to the tumor size, location and nature. Lateral rhinotomy-inner plate of frontal sinus-epidural approach can be carried out independently by the head and neck surgeons. It is a valuable surgical treatment with minimal invasion, short surgery time, little damage to brain, and easy pyrosis of skull base.