Résumé
Hepatitis B virus (HBV) infection is a major global public health problem. Persistent HBV infection is prone to develop chronic hepatitis B (CHB), and CHB is closely related to the development of liver fibrosis and hepatocellular carcinoma. High-affinity specific anti-HBs are essential for the control of HBV infection, while the antibody production is closely related to follicular helper T (Tfh) cells. Tfh cells can help B cells differentiate into plasma cells to produce specific antibodies to control virus infection. This article reviews the latest research progress of Tfh cells in HBV infection to provide information of new strategies for the prevention and treatment of HBV.
Résumé
Objective:To explore the application value and complications of two blood transfusion methods used for cesarean delivery.Methods:Sixty parturients undergoing cesarean delivery in Yiwu Central Hospital from January 2013 to December 2019 were included in this study. They were divided into autogenic blood transfusion and allogeneic blood transfusion groups ( n = 30/group) according to different blood transfusion methods used. In the autogenic blood transfusion group, self-storage blood transfusion scheme was used, while in the allogeneic blood transfusion group, allogeneic blood transfusion scheme was used. The amount of postpartum blood loss, amount of autogenic blood transfused, amount of allogeneic blood transfused, hemoglobin, hematocrit and coagulation index before and 3 days after surgery, complications were compared between autogenic blood transfusion and allogeneic blood transfusion groups. Results:Postoperative blood loss in the autogenic blood transfusion group was significantly less than that in the allogeneic blood transfusion group [(9 897.42 ± 215.37) mL vs. (23 081.87 ± 546.23) mL, t = 122.990, P < 0.05]. The amount of autogenic blood transfused in the autogenic blood transfusion group was less than that in the allogenic blood transfusion group [(954.32 ± 143.42) mL vs. (10 474.18 ± 376.87) mL, t = 129.310, P < 0.05). Hemoglobin level and hematocrit at 3 days after surgery in the autogenic blood transfusion group were (106.32 ± 12.19) g/L and (0.39 ± 0.19), which were significantly higher than those in the allogenic blood transfusion group [(86.18 ± 3.25) g/L, 0.34 ± 0.14, t = 8.744, 11.633, both P < 0.05]. D-Dimer and fibrin degradation product levels in the autogenic blood transfusion group were (5.45 ± 1.29) mg/L and (13.42 ± 2.41) mg/L, respectively, which were significantly lower than those in the allogenic blood transfusion group [(8.56 ± 1.47) mg/L, (21.30 ± 3.64) mg/L, t = 8.710, 9.887, P < 0.05]. The incidence of complications in the autogenic blood transfusion group was significantly lower than that in the allogenic blood transfusion group [6.67% (2/30) vs. 36.67% (11/30), χ2 = 7.954, P < 0.05]. Conclusion:Autogenic blood transfusion is highly effective for cesarean delivery of dangerous placenta previa, and it has few complications.