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OBJECTIVE:To study the effects of Astragali radix injection combined with entecavir on serum inflammatory cyto-kines and liver function of model mice with hepatitis B. METHODS:60 mice were randomly divided into normal control group (normal saline),model group (normal saline),Astragali radix injection group (0.5 mL/10 g),entecavir group (45 μg/kg) and combination group(0.5 mL/10 g Astragali radix injection+45 μg/kg entecavir),12 in each group. Except for normal control group, mice in other 4 groups were induced for hepatitis B models. After modeling,all mice were intragastrically administrated once a day,for 4 weeks. After administration,tumor necrosis factor α(TNF-α),interferon γ(IFN-γ),interleukin 8 (IL-8),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL)levels in serum were detected,and the pathologi-cal changes in liver tissue in each group were observed. RESULTS:Compared with normal control group,TNF-α,IFN-γ,IL-8, AST,ALT,TBIL levels in serum of mice in model group were significantly increased(P<0.05);and liver cells were diffuse and severe steatosis. Compared with model group,TNF-α,IFN-γ,IL-8,AST,ALT,TBIL levels in serum of mice in each administra-tion group were significantly decreased(P<0.05),pathological changes in liver tissue were improved to varying degrees,and the index improvement degree in combination group was superior to Astragali radix injection group and entecavir group (P<0.05). CONCLUSIONS:Astragali radix injection combined with entecavir helps to down-regulate the expressions of inflammatory cyto-kines of model mice with hepatitis B,and improve the liver function. The combination use has better effect than single use.
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OBJECTIVE:To investigate the effects of Cangfu daotan decoction combined with Clomiphene citrate capsule on sex hormone level and endometrial receptivity in patients with polycystic ovary syndrome (PCOS) combined infertility. METH-ODS:A total of 116 PCOS patients with infertility in the First Affiliated Hospital of Guiyang College of TCM from Jan. 2014 to Dec. 2014 were divided into observation group and control group according to random number table,with 58 cases in each group. Both groups received hormone regulation therapy since the fifth day of menstruation. Control group was given Clomiphene citrate capsule 50 mg,qd;observation group was additionally given one dose of Cangfu daotan decoction,400 mL after decocted with wa-ter,bid,on the basis of control group. Both groups were treated for 3 cycles of menstruation. The levels of serum sex hormone (E2,LH),endometrial thickness(Em),endometrial spiral arterial pulsatility index(PI)and resistance index(RI)were compared between 2 groups before and after treatment. The ovulation rate and pregnancy rate were compared between 2 groups after 1-year follow-up. RESULTS:Before treatment,there was no statistical significance in E2,LH,Em,PI or RI between 2 groups (P>0.05). After treatment,the levels of E2 and LH as well as Em in 2 groups were increased significantly,while PI and RI were de-creased significantly;the observation group was significantly better than the control group,with statistical significance(P0.05). The pregnancy rate of observation group was 41.38％,which was significantly higher than that of control group (22.41％),with statistical significance (P<0.05). CONCLUSIONS:Cangfu daotan decoction combined with Clomiphene citrate capsule can effectively regulate serum sex hormone levels of PCOS patients with infertility,and improve endometrial receptivity so as to increase pregnancy rate.
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Objective We aimed to discuss the influence of establishment of a hospital which makes people satisfied on nursing management. Methods We improved our nursing work by establishing quality-control groups, training staff, checking once a week and making feedback once a month through decomposing and subdividing the standard of building a hospital which makes people satisfied from March 2002 to December 2006. Results The qualified rate of nursing management increased from 69.3% to 97.6% every year, which has statistical difference (P<0.01). Conclusions Establishment of a hospital which makes people satisfied improved the general level of nursing management quality and nursing staff. We acquired good social and economic befenit.
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Objective To investigate the relationship between nodular goiter and thyroid cancer and the causes of postoperative recurrence in patients with nodular goiter(NG) undergoing operative treatment. Methods The clinical date of 199 cases of NG were retrospectively analysed. Results Pathological examination revealed that 7 cases were accompanied by thyroid cancer including 2 micro-cancer, all the 7 cases were papillary carcinomas. The postoperative recurrent rate of NG was 11.5%(18 cases).Thyroid nodule reccurrence rate in patients received - operative thyroxin replacement therapy was significantly lower than that in patients not received thyroxin therapy( P