RÉSUMÉ
Objective To investigate the clillicoradiologic characteristics of MarchiafavaBignami disease (MBD). Methods The clinical and neuroimaging findings, including lesion morphorogy, distribution, signal intensity/density in 7 MBD patients were retmspectiVely analyzed.Diffusion-weighted imaging(DWI)was performed in 5 cases.Of the 7 cases,4 underwent both CT and MRI,2 only CT and 1 MRI. Results with extensive iso-or slightly hypo-intensity on T1-weighted images and hyper-intensity on T2-weighted images, 5 patients were manifested as acute onset, in which white matter (WM) was symmetrically involved in bilateral periventricular and frontal subconical regions. Punctate or linear hypo-intensity on FLAIR images was found in the atrophied corpus callosum in 1 case presented as chronic type, with scattered patchy hyper-intensity in periventricular WM and frontal subcortical WM. DWI showed markedly hyper-intensity with diffusion restriction in 2 cases in acute phase with apparent diffusion coefficient(ADC)values(0.52～0.55)×10-3 mm2/s.Brain atrophy was found in all the 7 patients. Conclusions The MRI features of MBD are characteristic and may be associated with the clinical spectrum and prognosis.