RÉSUMÉ
Objective: To study the clinical value of home monitoring system of pacemaker and implantable cardioverter-deifbrillators (ICD) in relevant patients. Methods: A total of 33 patients with home monitoring system of pacemaker implantation or ICD treated in our hospital from 2011-02 to 2014-07 were retrospectively recruited. There were 28 patients with dual chamber pacemaker, 4 with ICD and 1 with cardiac resynchronization therapy pacemaker (CRTP). The patients included 23 male and 10 female at the age of (68.4 ± 9.2) years. The rate of successful data transmission, threshold changes and arrhythmia occurrence were analyzed. Results: Up to 2014-10, a total 24516 messages were successfully transmitted with the success rate of 97.4%, the rate of no-message transmission was 2.6%. The home monitoring system fund 89 abnormal events including 73 disease related events (82.0%) and 16 system related events (18.0%). Conclusion: Home monitoring system was a safe, reliable and effective monitoring equipment for cardiovascular implantable electronic devices; according to transmitted message, the parameters of devices could be adjusted in time for treating arrhythmia in relevant patients.
RÉSUMÉ
Objective To establish a mouse model of acute graft-versus-host disease (aGVHD) after allogeneic bone marrow transplantation,and using exogenous interleukin-7 receptor alpha (IL-7Rα) intervene mice aGVHD and analyse its possible mechanism.Methods The BALB/C (H-2d) female mice as recipients were grouped by rat: the irradiation group (group A),irradiation transplantation group (group B) and IL-7Rα in the intervention group (group C),each 10.ALL mice were accepted 9 Gy60Co total body irradiation.1×107 bone marrow cells and 2×107 spleen cells of donor C57BL/6 (H-2b) via the tail vein were infused to recipient mice.The signs of the recipient mice,hematopoietic functional recovery and survival time of change,and pathology,chimerism and cytokine levels in checkwere observed.Results Mice in A group after irradiation were gradually death,in group B and group C mice after transplantation had typical aGVHD symptoms,but lighter signs and a longer survival time of Group C than in group B.WBC count in Group C was +14 d (4.53± 0.21) ×109/L,+21 d (3.63±0.06) ×109/L,+28 d (4.31±0.04) ×109/L,was hematopoietic recovery compared with Group B [+14 d (1.81±0.05) ×109/L,+21 d (1.32±0.04) ×109/L,+28 d (1.76±0.04) ×109/L],the difference was statistically significant (t =0.237,0.108,0.359,P ＜ 0.05).The pathological results of liver,spleen,skin histopathology in group C were better than group B.Chimera implants,plasma IL-7 levels after transplant +7 d,concentration was significantly increased.IL-7 concentration in group C was +14 d (194.32±1.02) pg/ml,+21 d (131.63±1.54) pg/ml and in group B was +14 d (330.24±8.08) pg/ml,+21 d (184.09±2.05) pg/ml,the difference was statistically significant (t =1.590,1.285,P ＜0.05).Conclusion The stable aGVHD mouse model was established.In aGVHD early,plasma IL-7 levels were significantly increased.Exogenous IL-7Rαcan reduce the plasma IL-7 levels,thereby reducing the incidence of aGVHD after allogeneic bone marrow transplantation.