Clinical significance of combined Tests with malignant tumor in digestive system / 中国基层医药

Objective To investigate the clinical value of combined tests,including A-fetus protein(AFP)、cancer embryo agent(CEA),carbonhydrate agent 19-9(CA19-9)for the diagnosis of malignant tumors in digestive system.Methods Chemicalill-umination tests were used to detect serum levels of AFP,CEA and CA 19-9 in 821 patients with diseases of digestive system.Results The levels of AFP,CEA,CA19-9 in malignant group and the benign group were significantly higher than the control group(t=2.345,2.224,all P＜0.05;t=2.785,2.749,2.897,2.865,all P＜0.01＝;The levels of AFP、CEA、CA19-9 in malignant group were significantly higher than benign group (t=2.445,P＜0.05;t=2.745,2.819,all P＜0.01);The level of AFP in liver cancer group was significantly hisher than other groups(t=2.715,2.812,2.877,2.845,2.799,all P＜0.01);The level of CEA in hver cancer group was significantly lower in patients with liver colorectal cancer and pancreatic cancer(t=2.775,2.801,all P＜0.01);The level of CA19-9 in bile duct cancer group was significantly hisher than that of other cancers (t=2.733,2.851,2.788,all P＜0.01);The positive rates of liver、stomach、colorectal cancer、pancreatic cancer、bile duct cancer combined detection in three item were 91.0%,90.0,88.0%,90.0%,70.2%which were higher than the single check-positive rate of 85.0%,72.0%,67.5%,79.4%、55.3%(χ2=3.781,3.841,3.798,3.814,3.994,all P＞0.05).Conclusion The three tumor markers could be used as auxiliary diagnostic and ioint detection which could improve the detection rate in patients with malignant tumors of digestive system.

Experimental Study on Hypoglycemic Effect of Huangsang Oral Solution / 中国药房

OBJECTIVE:To observe the hypoglycemic effects of Huangsang oral solution.METHODS:Diabetes models of mice was induced with alloxan then the mice were randomly divided into the NS group,model control group,phenformin group,and high dose,middle dose and low dose Huangsang oral solution groups(30.0 g?kg-1,15.0 g?kg-1 and 8.0 g?kg-1).The corresponding drugs were given by ig bid for 10 days.Blood glucose was measured with glucose oxidas method.The effects of Huangsang oral solution on blood glucose concentration and glucose tolerance in diabetic mice as well as on blood glucose concentration in the normal mice were observed.RESULTS:The different dose of Huangsang oral solution could decrease the blood glucose level significantly and improve glucose tolerance in alloxan-induced diabetes mice,and the effect was significant compared with the model control group(P