RÉSUMÉ
@#To explore the differences in cognitive function between different subtypes of chronic insomnia，including the diferences of incidence of cognitive dysfunction and the cognitive domain of each subtype. Methods To collect patients diagnosed as chronic insomnia in the neurology department of Cardiovascular and Cerebrovascular Hospital of Ningxia Medical University from January 2018 to December 2018（65 cases in total）. Polysomnography（PSG） was used to classify patients with insomnia objectively. 14 cases were sleep difficultly，12 cases were awakened early，16 cases were difficult to maintain，and 23 cases were mixed. On the morning of the completion of PSG，to evaluate the cognitive function of patients with the Montreal Cognitive Assessment（MoCA）. Results （1）The incidence of cognitive impairment in different subtypes of chronic insomnia was different（χ2=8.004，P<0.05），and the mixed group was more prone to cognitive dysfunction. （2）The delayed recall scores of patients with different subtypes of insomnia were different（H=13.239，P<0.05），and the scores of the mixed group were lower than other groups（P<0.05）. Conclusion The incidence of cognitive dysfunction among different subtypes of chronic insomnia was different，the mixed type was more prone to cognitive impairment. The delayed recall ability varied among different types，the mixed type was worse.
RÉSUMÉ
@#Objective To explore the correlation between cerebral microbleeds and cognitive dysfunction as well as the risk factors affecting the occurrence of cognitive dysfunction.Methods A total of 113 patients with no abnormalities by transcranial magnetic resonance imaging scans admitted to our hospital from May 2018 to June 2019,clinical risk factors were recorded.MoCA was tested for cognitive function assessment.MoCA score≥26 was divided into normal cognitive function group,MoCA score<26 was divided into cognitive dysfunction,and both groups were scanned with susceptibility weighted imaging.Analyze the clinical risk factors that affect the MoCA score and the relationship between the number,incidence, anatomic location and MoCA score of cerebral cerebral microbleeds.Results There was a statistical difference in the years of education between the two groups of patients (P<0.05).The number of cerebral microbleeds lesions and the positive of cerebral microbleeds lesions were negatively correlated with the MoCA score (P<0.05).There was a negative correlation between basal ganglia microbleeds and MOCA score (P<0.05).Conclusion Few years of education may be an independent risk factor for cognitive dysfunction,and cerebral microbleeds are closely related to the occurrence of cognitive dysfunction.
RÉSUMÉ
Objective To study the gene mutation characteristics of patients with spinocerebellar ataxias(SCA) in Ningxia region.Methods The SCA3/Machado-Joseph disease(MJD)trinucleotide CAG repeat number was detected by polymerase chain reaction(PCR),capillary gel electrophoresis(CGE) and DNA sequencing in 6 patients with SCAs and 4 normal kindreds from a family in Ningxia region.Results All patients and 1 kindred were positive for SCA3/MJD;other 3 kindreds were negative for SCA3/MJD.The CAG repeat number was expanded to 66～81 in the patients with SCA3/MJD and a kindred,and 22～33 in other 3 kindreds.Conclusion There is SCA3/MJD in the patients with SCAs of Ningxia region.Gene examining has the great significance for definite diagnosis in the patients with SCAs.