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Objective To explore the efficacy of moderate dose bromocriptine by one-off oral administration in treatment of patients with non-acute prolactin (PRL) type pituitary adenoma.Methods Forty-three patients with definite diagnosis of non-acute prolactin type pituitary adenoma,admitted to our hospital from January 2016 to December 2017,were chosen in our study.All patients were administrated with 5 mg bromocriptine at 18 pm;the serum PRL levels were examined at 2,3 and 12 h after bromocriptine administration.The curative effects of these patients were judged by decline rate of PRL,and the curative effects of patients with different genders,different initial PRL levels and different ages were compared.Results In these 43 patients,bromocriptine showed excellent effect in 20 patients,obvious effect in 18 and invalid effect in 5.There were statistically significant differences in the efficacy of bromocriptine between different genders (P＜0.05).There were statistically significant differences in efficacy of patients with different genders after taking bromocriptine (P＜0.05).The female patients had obviously higher rate of obvious effect than the male patients.Patients with different initial PRL values had statistically significant differences in efficacy after taking bromocriptine (P＜0.05).Patients with PRL initial value of 40-200 ng/mL had significantly higher rate of obvious effect than patients with PRL initial value of ＞200 ng/mL.There was no significant difference in efficacy between patients ＜ 45 years old and patients＞45 years old (P＞0.05).Conclusion The treatment ofhyperprolactin caused by prolactin type pituitary adenoma with moderate dose bromocriptine by one-off oral administration is effective;female patients have obviously better effect than male patients;and for patients with initial prolactin＞200 ng/mL,the effect is better.
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Objective To explore the effects of antenatal premium care on the improvement of negative emotions and pregnancy outcomes for patients with gestational hypertension. Methods A total of 128 patients with gestational hyper-tension who were admitted to our hospital from June 2013 to January 2014 were selected as research subjects. They were randomly assigned to two groups, who received antenatal premium care (observation group) and regular nursing care (control group). SAS and SDS scores before and after admission, premature delivery, cesarean section, placental abruption, postnatal hemorrhage, eclampsia, pre-eclampsia, fetal distress, low birth weight, neonatal asphyxia, death, Apgar scores and life quality were compared. Results After antenatal premium care in the observation group, SAS and SDS scores were (41.42±5.16) and (40.29±5.41) respectively;After antenatal premium care in the control group, SAS and SDS scores were (50.27±5.49) and (48.73±5.63) respectively. Before the antenatal premium care, SAS and SDS scores between the two groups were not statistically significant (P>0.05). After the antenatal premium care, SAS and SDS scores in the observation group were significantly lower than those in the control group, and the differences were statis-tically significant (P<0.05). Differences of negative outcomes compared between the two groups of patients were statisti-cally significant (P<0.05). Differences of negative outcomes compared between the two groups of perinatal infants were statistically significant (P<0.05). Scores of life quality of patients in the observation group were all better than those in patients in the control group, and the differences were statistically significant (P<0.05). Conclusion Antenatal premium nursing is able to effectively ease the negative emotion of patients with gestational hypertension and enhance the out-come of mother and infants.
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One leading research target of modern tumor radiotherapy is to increase radiosensitization of tumor and improve curative effect of radiotherapy.Histone deacetylase inhibitors are epigenetic drugs that can play a part in radiosensitization through means of induction of apoptosis,inhibition of repair of DNA doublestrand breaks,cell cycle arrest,improvement of tumor cell hypoxia and increase of reactive oxygen species.There is an urgent need to develop biomarkers based on these pathways,which can promote clinically individualized treatment.
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0.05).Conclusion The expression of TM in different TCM syndromes of gastric carcinoma was different.There exists a certain relation in the expression of TM1 and TM2 in different TCM syndromes of gastric cancer.
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Objective To observe the therapeutic effect of Sanzi Yangqing Decoction (Decoction of three kinds of seeds) for mammary cystic hyperplasia.Methods Totally 113 patients with mammary cystic hyperplastia were randomized into a treatment group (58 cases) which was prescribed Sanzi Yangqing Decoction and a control group (55 cases) which was given Ruhe Sanjie Tablet (Tablet for dissolving mammary masses). Both were treated for 3 courses. Before and after treatment the clinical symptoms and signs, hormones in serum of both groups, and the indices of hemodynamics of the treatment group were observed.Results The total effective rate of the treatment group was 89.66%, while that of the control group was 65.45%, there was significant difference (P