Studies on the peritoneal fluid clotting and fibrinolytic activities

The clotting and fibrinolytic activities of samples of peritoneal fluid from 83 female patients with primary infertility were studied. Peritoneal fluid did not clot spontaneously on collection due to lack of prothrombin activation consequent upon virtual absence of factor VIII. The PF had a high concentration of fibrinogen in the luteal phase of the cycle and in patients with endometriosis and pelvic adhesion formation. It also had a fibrinolytic activity as demonstrated by the presence of FDPs. The initiation of this activity is a crucial factor in the final development of peritoneal pelvic adhesions

Biochemical studies on human cervical mucous in infertility

We studied 25 infertile women in whomn in whom cervical hostility was the only known cause of infertility, and 10 fertile women. Total soluble proteins, IgG, IgA and IgM togeter with zinc, copper manganese and lead were measured in mid-menstrual cycle cervical mucus. IgG and IgA were present in the cervical mucus of all the women. But IgM was detected only in 20% of samples of fertile women and in 36% of samples of infertile women. Levels of IgA and total soluble proteins were significantly higher in the infertile group. Zinc, Copper and manganese were present in cervical mucus and the concentrations found did not differ significantly in the tow groups. Lead was not detected in all cervical mucus samples in the two groups