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China Journal of Chinese Materia Medica ; (24): 559-563, 2004.
Article Dans Chinois | WPRIM | ID: wpr-256307

Résumé

<p><b>OBJECTIVE</b>To analyse the effects of buyang huanwu decoction (BYHWT) on differentially expressed genes during cerebral ischemia/reperfusion in rats with DNA microarray.</p><p><b>METHOD</b>cDNA microarray chips containing 512 cDNAs were made by Biostar Genechip Inc. Sprague-Dawley rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) with an filament. Saline or BYHWT was given p.o. after onset of cerebral ischemia and brains were removed after 24 h of recirculation for mRNAs isolation. A differential measurment of mRNAs from post-ischemic and BYHWT treated animals was performed with microarray.</p><p><b>RESULT</b>Up-and down-regulated genes were 69 and 80 in ischemic group. Up-and down-regulated genes were 25 and 6 in BYHWT treated group.</p><p><b>CONCLUSION</b>BYHWT regulates the differential expression genes after focal brain ischemia/reperfusion in rats, due to its mechanism of protecting cerebral ischemia/reperfusion injury.</p>


Sujets)
Animaux , Mâle , Rats , Encéphalopathie ischémique , Génétique , Médicaments issus de plantes chinoises , Pharmacologie , Analyse de profil d'expression de gènes , Neuroprotecteurs , Pharmacologie , Séquençage par oligonucléotides en batterie , Rat Sprague-Dawley , Lésion d'ischémie-reperfusion , Génétique
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