Expresión y efecto del gen de VEGF165 humano en músculo esquelético isquémico de conejos. ¿Necesidad de administración repetitiva para el tratamiento de la enfermedad vascular periféica? / Expression and effects after VEGF165 gene transfer: is it necessary the reiterative administration for the treatment of peripheral vascular disease?

Peripheral vascular disease is a disorder fifficult to treat. Due to the lack of an effective pharmacological therapy, the ischemia of an effective pharmacological therapy, the ischemia of the lower limbs pursues a relentless course, ending many times in the amputation...The authors present in this study a 6 years experience with this management, and recently the effects of an experimental model of peripheral vascular disease in rabbits is evaluated. The results obtained in this study are important because they could attribute to he trnasitority of the genetic expression the contradictory results founded in clinical assays of peripheral vascular disease

Nuevo modelo experimental de Estenosis Valvular Aórtica / New experimental model of aortic valve stenosis in rabbits

Aortic valve stenosis is a chronic progressive disease, being the most common type of valvular disease in developed countries. Despite its increasing incidence, both molecular and celular mechanisms of the disorder have not been adequately determined, in part because of lack of appropriate experimental models. This study was designed to assay an experimental new model of aortic valve stenosis in hypertensive rabbits which could be useful to study the early evolution of the disease, and also to test different pharmacological treatments to prevent its progression