Résumé
Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract [TPE] on lipid peroxidation and acute heart injury induced by carbon tetrachloride [CCl4] in rats
Materials andmethods: In an experimental study, 30 male Wistar rats were divided into 5 groups [n=6]. Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl4. At the end of the study we measured the activity of creatine kinase [CK-MB] isoenzyme and lactate dehydrogenase [LDH], total cholesterol [TC], HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase [SOD], glutathione peroxidase [GPX], and arylesterase [ARE] and malondialdehyde [MDA] concentration, as lipid peroxidation index, in myocardial homogenates
Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GPX [P <0.001] in a dose dependent manner
Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as antioxidant activity and cardioprotective effects